5 Cities with the Highest Opioid Deaths in the U.S.

2. Cleveland, Ohio

Opioid-related drug overdose deaths (per 100,000 population, age-adjusted): 58.5

Cleveland makes Ohio the only state to appear twice on our list of cities with the most opioid related deaths. Cleveland was founded a handful of years before the turn of the nineteenth century. It houses several important Fortune 500 firms and is known for Cleveland Clinic which is one of the best hospitals in the U.S.