5 Biggest US Cities Facing Depopulation by 2100

3. St. Louis, MO

Five-Year Change: -7.14%

Annual Loss Rate: -1.356%

St. Louis has been faced with a population decline for several years now. Between April 2020 and July 2022, the entire St. Louis region lost around 19,000 people. Moreover, the population decline was seen in both younger and older age groups. Several factors have led to the decrease in the city’s population. These include a tight job market, a higher crime rate as compared to other cities, the migration of residents to suburban areas, and demographic and economic shifts in the Midwestern region.