5 Biggest US Cities Facing Depopulation by 2100

4. Baltimore, MD

Five-Year Change: -6.82%

Annual Loss Rate: -0.753%

Baltimore has been observing a population decline for decades now, with 2022 statistics indicating a decrease of 1.2%. This led to the city’s total population declining to about 569,930, a number last seen in the early 1910s. Job losses, along with various economic challenges, high crime rates, and suburbanization, have led to a decreasing population.