5 Biggest Ohio Companies and Stocks

3. Cardinal Health, Inc. (NYSE:CAH)

Total revenue (in millions): $162,467

Total market cap as at 2nd Jan 2023 (in millions): $20,150

In terms of revenue, Cardinal Health, Inc. (NYSE:CAH) is the biggest company in terms of revenue headquartered in Ohio. Currently, Cardinal Health, Inc. (NYSE:CAH) has close to 50,000 employees. While Cardinal Health, Inc. (NYSE:CAH) has outperformed the S&P 500 by a large margin in 2022, over a longer term (from late 2017 onwards), the company has actually underperformed the S&P 500.