5 Biggest Industries in the US Heading into 2023

4. Health care and social assistance

Average gross domestic product of the industry in 2021 (in billions): 1,799.3

Gross domestic product of the industry in Q1 2022 (in billions): 1,820.3

Healthcare is one of the biggest industries in the U.S. in 2023. Major players in the industry are CVS Health Corporation (NYSE:CVS) and UnitedHealth Group Incorporated (NYSE:UNH).