In this article, we will list the 5 Best Upside Stocks to Buy According to Analysts. Please visit 9 Best Upside Stocks to Buy According to Analysts to see the extended list and the methodology behind it.
5. Praxis Precision Medicines Inc. (NASDAQ:PRAX)
Average Upside Potential: 59.90%
Praxis Precision Medicines Inc. (NASDAQ:PRAX) is one of the best upside stocks to buy according to analysts. On April 14, Praxis Precision Medicines announced that the US FDA accepted its NDA for ulixacaltamide HCl. This treatment is intended for adults living with essential tremor/ET, a central nervous system condition. The FDA has established a Prescription Drug User Fee Act/PDUFA target action date of January 29, 2027, and currently does not anticipate holding an advisory committee meeting as part of the review process.
The application is supported by data from the Essential3 Phase 3 program, which included two pivotal studies demonstrating statistically and clinically significant results. Throughout these trials, ulixacaltamide was generally well tolerated, maintaining a safety profile consistent with earlier research and reporting no drug-related serious adverse events. This regulatory milestone follows the FDA’s decision to grant the therapy Breakthrough Therapy Designation in December 2025.
Ulixacaltamide is a selective small molecule inhibitor designed to target T-type calcium channels to block abnormal neuronal firing associated with tremor activity. As the leading program in the company’s Cerebrum small molecule platform, it represents a precision neuroscience approach to treating ET. Praxis Precision Medicines Inc. (NASDAQ:PRAX) is now focusing on the review process and preparing for a potential commercial launch to provide a therapy developed specifically for this patient population.
Praxis Precision Medicines Inc. (NASDAQ:PRAX) is a clinical-stage biopharmaceutical company engaging in the development of therapies for central nervous system disorders characterized by neuronal excitation-inhibition imbalance.
4. ServiceNow Inc. (NYSE:NOW)
Average Upside Potential: 62.68%
ServiceNow Inc. (NYSE:NOW) is one of the best upside stocks to buy according to analysts. On April 20, ServiceNow completed its $7.75 billion cash acquisition of Armis, a leader in cyber exposure management. This move extends ServiceNow’s security capabilities into the physical and operational layers of the enterprise, covering IT, OT, IoT, and medical devices.
By integrating Armis’ real-time asset intelligence with its existing platform, ServiceNow Inc. (NYSE:NOW) aims to provide a unified AI control tower that bridges the gap between detecting vulnerabilities and executing automated remediation. This acquisition follows the March purchase of Veza, which brought AI-native identity intelligence to the ServiceNow platform. Together, Armis and Veza allow organizations to secure the expanding attack surface created by agentic AI, mapping every connected asset and identity permission.
The combination of these tools powers ServiceNow’s Context Engine, allowing the platform to prioritize risks automatically and execute autonomous, auditable workflows that align with specific business realities. To lead the transition toward autonomous security, ServiceNow is establishing a global AI Center for Cyber Defense. This hub will focus on developing AI-native security stacks to neutralize threats before they occur, helping organizations move away from reactive legacy frameworks.
ServiceNow Inc. (NYSE:NOW) provides cloud-based and AI-embedded end-to-end workflow automation solutions for enterprises. The company is located in Santa Clara, California, and was founded in June 2004 by Frederic B. Luddy.
3. EquipmentShare.com Inc. (NASDAQ:EQPT)
Average Upside Potential: 66.45%
EquipmentShare.com Inc. (NASDAQ:EQPT) is one of the best upside stocks to buy according to analysts. On March 18, EquipmentShare reported strong financial growth for 2025, marked by a 34% increase in Rental Segment revenue to $2.7 billion. Total revenue for the full year reached $4.379 billion, supported by significant customer demand and the aggressive expansion of the company’s physical footprint. During this milestone year, which included the company’s IPO, EquipmentShare opened 95 new locations, bringing its total operational count to 385 sites.
Profitability saw a sharp rise, with full-year net income climbing to $40 million, a significant jump from $3 million in 2024. Adjusted Core EBITDA also grew by 32% to $1.667 billion, driven by the maturation of existing rental sites and a 33% increase in the original equipment cost under management, which ended the year at $8.780 billion. Despite an 8% decrease in equipment sales due to selective participation in the OWN Program, the company remained oversubscribed across its investor channels.
For 2026, EquipmentShare.com Inc. (NASDAQ:EQPT) expects a supportive industry backdrop driven by large-scale infrastructure, data center, and energy projects. The company’s guidance projects total revenue between $5.051 and $5.471 billion, with plans to reach up to 429 full-service rental locations. Management intends to use its T3 technology platform and AI capabilities to further improve jobsite efficiency and scale its capital-efficient growth model.
EquipmentShare.com Inc. (NASDAQ:EQPT) provides construction equipment rental, sales, and technology solutions.
2. Kratos Defense & Security Solutions Inc. (NASDAQ:KTOS)
Average Upside Potential: 75.05%
Kratos Defense & Security Solutions Inc. (NASDAQ:KTOS) is one of the best upside stocks to buy according to analysts. On April 21, Kratos Defense & Security Solutions completed the initial flight series of the Mk1 Firejet, a new configuration of its Firejet unmanned aerial system/UAS integrated with the Kratos J85 engine. This high-performance version was developed in collaboration with the US Army Target Systems Management Office/TSMO to provide enhanced aero-performance while remaining in an affordable sub-$500,000 price class.
The J85-powered Firejet offers significant improvements in speed, range, and climb rate, serving as a versatile platform for both aerial target missions and tactical drone operations. The expansion of the Firejet line coincides with the ramp-up of the Kratos Spartan engine production facility, which was established in late 2025. This facility is expected to produce thousands of engines this year, reaching tens of thousands over the next few years to address the depletion of US and ally inventories.
By using an American-made engine with domestically sourced components, Kratos Defense & Security Solutions Inc. (NASDAQ:KTOS) aims to mitigate supply chain risks while meeting the Department of War’s demand for affordable, military-grade capabilities that can be deployed today. This new configuration positions the Firejet as the first-to-market tactical jet UAS of its class, offering fighter-like performance for training and weapons testing.
Kratos Defense & Security Solutions Inc. (NASDAQ:KTOS) is a technology company focused on the development of advanced products and systems for defense, national security, and commercial markets.
1. Guidewire Software Inc. (NYSE:GWRE)
Average Upside Potential: 75.84%
Guidewire Software Inc. (NYSE:GWRE) is one of the best upside stocks to buy according to analysts. On April 16, Guidewire launched ProNavigator, a role-specific AI assistant embedded within its InsuranceSuite and InsuranceNow applications. Introduced as part of the Palisades release, the tool is designed to provide underwriters, claims adjusters, and billing specialists with context-aware insights directly within their existing workflows.
By grounding AI responses in an insurer’s unique source material and providing citations, the assistant aims to scale expertise while ensuring that decision-making remains accurate and dependable. The platform emphasizes security and control through the use of role-based access controls and detailed audit trails. This human-in-the-loop approach ensures that AI-generated intelligence remains governed and that only authorized personnel can access specific sensitive documents.
ProNavigator is built to be production-ready from day one, reducing the typical maintenance burden and time-to-value for Property & Casualty insurers looking to move from AI experimentation to operational adoption. Additionally, the Palisades release introduces several broader functional updates, including the Jutro Developer Assistant for building digital experiences and enhanced funds tracking for financial reconciliation. The update also features a redesigned claims experience for the London Market and integrated pricing capabilities within PolicyCenter.
Guidewire Software Inc. (NYSE:GWRE) offers a cloud-based platform for property and casualty (P&C) insurers worldwide. The platform provides several applications, such as PolicyCenter, ClaimCenter, and BillingCenter, that facilitate core operations for P&C insurance companies.
While we acknowledge the potential of GWRE to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than GWRE and that has 100x upside potential, check out our report about the cheapest AI stock.
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