13G Filing: Perceptive Advisors and Histogenics Corp (HSGX)

---

Item 1(a).

Name of Issuer:

Histogenics Corporation (the Issuer)

Item 1(b).

Address of Issuers Principal Executive Offices:

830 Winter
Street, 3rd Floor, Waltham, Massachusetts 02451

Item 2(a).

Names of Persons Filing:

The names of the persons filing this
report (collectively, the Reporting Persons) are:

Perceptive Advisors LLC (Perceptive Advisors)

Joseph Edelman (Mr. Edelman)

Perceptive Life Sciences Master Fund, Ltd. (the Master Fund)

Item 2(b).

Address of Principal Business Office or, if None, Residence:

The
address of the principal business office of each of the Reporting Persons is:

51 Astor Place, 10th Floor

New York, NY 10003

Item 2(c).

Citizenship:

Perceptive Advisors is a Delaware limited liability
company

Mr. Edelman is a United States citizen

The Master Fund is a Cayman Islands corporation

Item 2(d).

Title of Class of Securities:

Common Stock,
$0.01 par value per share (Common Stock)

Item 2(e).

CUSIP Number:

43358V 10 9

Item 3.

If this statement is filed pursuant to §§ 240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:

Not applicable.

Item 4.

Ownership.

The information required by this item with respect to each Reporting
Person is set forth in Rows 5 through 9 and 11 of the cover page to this Schedule 13G. The ownership percentages reported are based on 25,131,496 outstanding shares of Common Stock, as reported in the Issuers prospectus filed on
January 24, 2018.