13G Filing: Cormorant Global Healthcare Master Fund and Proteostasis Therapeutics, Inc. (PTI)

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Ownership Summary Table

Name Sole Voting Power Shared Voting Power Sole Dispositive Power Shared Dispositive Power Aggregate Amount Owned Power Percent of Class
Cormorant Global Healthcare Master Fund 0 1,450,825 0 1,450,825 1,450,825 7.6%
Cormorant Global Healthcare GP 0 1,450,825 0 1,450,825 1,450,825 7.6%
Cormorant Asset Management 0 1,725,460 0 1,725,460 1,725,460 9.0%
Bihua Chen 0 1,725,460 0 1,725,460 1,725,460 9.0%

Page 1 of 8 SEC Filing

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
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OMB Number:3235-0145
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SCHEDULE 13G
Under the Securities Exchange Act of 1934
(Amendment No. ___)*
Proteostasis Therapeutics, Inc.
(Name of Issuer)
Common Stock, par value $0.001 per share
(Title of Class of Securities)
74373B109
(CUSIP Number)
February 16, 2016
(Date of Event which Requires Filing of this Statement)
Check the appropriate box to designate the rule pursuant to which this Schedule is filed:
[ ]            Rule 13d-1(b)
[x]            Rule 13d-1(c)
[ ]            Rule 13d-1(d)
___________________________________
The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

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Page 2 of 8 SEC Filing

1
Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only)
Cormorant Global Healthcare Master Fund, LP
2
Check the Appropriate Box if a Member of a Group (See Instructions)
(a)            [ ]
(b)            [x]
3
SEC Use Only
4
Citizenship or Place of Organization.
Cayman Islands
Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With
5  Sole Voting Power
0 shares
6  Shared Voting Power
1,450,825 shares (1,466,734 shares as of February 26, 2016)
Refer to Item 4 below.
7  Sole Dispositive Power
0 shares
8  Shared Dispositive Power
1,450,825 shares (1,466,734 shares as of February 26, 2016)
Refer to Item 4 below.
9
Aggregate Amount Beneficially Owned by Each Reporting Person
1,450,825 shares (1,466,734 shares as of February 26, 2016)
Refer to Item 4 below.
10
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)     [ ] N/A
11
Percent of Class Represented by Amount in Row (9)*
7.6% (7.7% as of February 26, 2016)
Refer to Item 4 below.
12
Type of Reporting Person (See Instructions)
PN (Partnership)

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Page 3 of 8 SEC Filing

1
Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only)
Cormorant Global Healthcare GP, LLC
2
Check the Appropriate Box if a Member of a Group (See Instructions)
(a)            [ ]
(b)            [x]
3
SEC Use Only
4
Citizenship or Place of Organization.
Delaware
Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With
5  Sole Voting Power
0 shares
6  Shared Voting Power
1,450,825 shares (1,466,734 shares as of February 26, 2016)
Refer to Item 4 below.
7  Sole Dispositive Power
0 shares
8  Shared Dispositive Power
1,450,825 shares (1,466,734 shares as of February 26, 2016)
Refer to Item 4 below.
9
Aggregate Amount Beneficially Owned by Each Reporting Person
1,450,825 shares (1,466,734 shares as of February 26, 2016)
Refer to Item 4 below.
10
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)     [ ] N/A
11
Percent of Class Represented by Amount in Row (9)*
7.6% (7.7% as of February 26, 2016)
Refer to Item 4 below.
12
Type of Reporting Person (See Instructions)
OO (Limited Liability Company)

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Page 4 of 8 SEC Filing

1
Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only)
Cormorant Asset Management, LLC
2
Check the Appropriate Box if a Member of a Group (See Instructions)
(a)            [ ]
(b)            [x]
3
SEC Use Only
4
Citizenship or Place of Organization.
Delaware
Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With
5  Sole Voting Power
0 shares
6  Shared Voting Power
1,725,460 shares (1,744,399 shares as of February 26, 2016)
Refer to Item 4 below.
7  Sole Dispositive Power
0 shares
8  Shared Dispositive Power
1,725,460 shares (1,744,399 shares as of February 26, 2016)
Refer to Item 4 below.
9
Aggregate Amount Beneficially Owned by Each Reporting Person
1,725,460 shares (1,744,399 shares as of February 26, 2016)
Refer to Item 4 below.
10
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)     [ ] N/A
11
Percent of Class Represented by Amount in Row (9)*
9.0% (9.1% as of February 26, 2016)
Refer to Item 4 below.
12
Type of Reporting Person (See Instructions)
OO (Limited Liability Company)

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Page 5 of 8 SEC Filing

1
Names of Reporting Persons.
I.R.S. Identification Nos. of above persons (entities only)
Bihua Chen
2
Check the Appropriate Box if a Member of a Group (See Instructions)
(a)            [ ]
(b)            [x]
3
SEC Use Only
4
Citizenship or Place of Organization.
United States
Number
of Shares
Beneficially
Owned by
Each
Reporting
Person With
5  Sole Voting Power
0 shares
6  Shared Voting Power
1,725,460 shares (1,744,399 shares as of February 26, 2016)
Refer to Item 4 below.
7  Sole Dispositive Power
0 shares
8  Shared Dispositive Power
1,725,460 shares (1,744,399 shares as of February 26, 2016)
Refer to Item 4 below.
9
Aggregate Amount Beneficially Owned by Each Reporting Person
1,725,460 shares (1,744,399 shares as of February 26, 2016)
Refer to Item 4 below.
10
Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)     [ ] N/A
11
Percent of Class Represented by Amount in Row (9)*
9.0% (9.1% as of February 26, 2016)
Refer to Item 4 below.
12
Type of Reporting Person (See Instructions)
IN (Individual)

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Page 6 of 8 SEC Filing

Item 1.
(a)
Name of Issuer
Proteostasis Therapeutics, Inc.
(b)
Address of Issuer’s Principal Executive Offices
200 Technology Square, 4th Floor
Cambridge, Massachusetts 02139
Item 2.
(a)
Name of Person Filing
Cormorant Global Healthcare Master Fund, LP
Cormorant Global Healthcare GP, LLC
Cormorant Asset Management, LLC
Bihua Chen
(b)
Address of Principal Business Office or, if none, Residence
200 Clarendon Street, 52nd Floor
Boston, MA 02116
(c)
Citizenship
Cormorant Global Healthcare Master Fund, LP – Cayman Islands
Cormorant Global Healthcare GP, LLC – Delaware
Cormorant Asset Management, LLC – Delaware
Bihua Chen – United States
(d)
Title of Class of Securities
Common Stock
(e)
CUSIP Number
74373B109

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Page 7 of 8 SEC Filing

Item 3. If this statement is filed pursuant to §§240.13d-1(b) or 240.13d-2(b) or (c), check whether the person filing is a:
(a)
[ ]
Broker or dealer registered under section 15 of the Act (15 U.S.C. 78o).
(b)
[ ]
Bank as defined in section 3(a)(6) of the Act (15 U.S.C. 78c).
(c)
[ ]
Insurance Company as defined in Section 3(a)(19) of the Act
(d)
[ ]
Investment company registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).
(e)
[ ]
An investment adviser in accordance with §240.13d-1(b)(1)(ii)(E);
(f)
[ ]
An employee benefit plan or endowment fund in accordance with §240.13d-1(b)(1)(ii)(F);
(g)
[ ]
A parent holding company or control person in accordance with § 240.13d-1(b)(1)(ii)(G);
(h)
[ ]
A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813);
(i)
[ ]
A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3);
(j)
[ ]
A non-U.S. institution in accordance with §240.13d–1(b)(1)(ii)(J);
(k)
[ ]
Group, in accordance with §240.13d-1(b)(1)(ii)(K).
Item 4. Ownership***
Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.
(a)
Amount Beneficially Owned***
Cormorant Global Healthcare Master Fund, LP – 1,450,825 shares (1,466,734 shares as of February 26, 2016)
Cormorant Global Healthcare GP, LLC – 1,450,825 shares (1,466,734 shares as of February 26, 2016)
Cormorant Asset Management, LLC – 1,725,460 shares (1,744,399 shares as of February 26, 2016)
Bihua Chen – 1,725,460 shares (1,744,399 shares as of February 26, 2016)
(b)
Percent of Class
Cormorant Global Healthcare Master Fund, LP – 7.6% (7.7% as of February 26, 2016)
Cormorant Global Healthcare GP, LLC – 7.6% (7.7% as of February 26, 2016)
Cormorant Asset Management, LLC – 9.0% (9.1% as of February 26, 2016)
Bihua Chen – 9.0% (9.1% as of February 26, 2016)
(c)
Number of shares as to which such person has:
(i)
sole power to vote or to direct the vote
Cormorant Global Healthcare Master Fund, LP – 0 shares
Cormorant Global Healthcare GP, LLC – 0 shares
Cormorant Asset Management, LLC – 0 shares
Bihua Chen – 0 shares
(ii)
shared power to vote or to direct the vote
Cormorant Global Healthcare Master Fund, LP – 1,450,825 shares (1,466,734 shares as of February 26, 2016)
Cormorant Global Healthcare GP, LLC – 1,450,825 shares (1,466,734 shares as of February 26, 2016)
Cormorant Asset Management, LLC – 1,725,460 shares (1,744,399 shares as of February 26, 2016)
Bihua Chen – 1,725,460 shares (1,744,399 shares as of February 26, 2016)
(iii)
sole power to dispose or to direct the disposition of
Cormorant Global Healthcare Master Fund, LP – 1,450,825 shares (1,466,734 shares as of February 26, 2016)
Cormorant Global Healthcare GP, LLC – 1,450,825 shares (1,466,734 shares as of February 26, 2016)
Cormorant Asset Management, LLC – 1,725,460 shares (1,744,399 shares as of February 26, 2016)
Bihua Chen – 1,725,460 shares (1,744,399 shares as of February 26, 2016)
(iv)
shared power to dispose or to direct the disposition of
Cormorant Global Healthcare Master Fund, LP – 1,450,825 shares (1,466,734 shares as of February 26, 2016)
Cormorant Global Healthcare GP, LLC – 1,450,825 shares (1,466,734 shares as of February 26, 2016)
Cormorant Asset Management, LLC – 1,725,460 shares (1,744,399 shares as of February 26, 2016)
Bihua Chen – 1,725,460 shares (1,744,399 shares as of February 26, 2016)
*** Shares reported herein for Cormorant Asset Management, LLC represent shares which are beneficially owned by Cormorant Global Healthcare Master Fund, LP (the “Fund”), as reported herein, and shares which are beneficially owned by a managed account (the “Account”).  Cormorant Global Healthcare GP, LLC serves as the general partner of the Fund, and Cormorant Asset Management, LLC serves as the investment manager to both the Fund and the Account.  Bihua Chen serves as the managing member of Cormorant Global Healthcare GP, LLC and Cormorant Asset Management, LLC.  Each of the Reporting Persons disclaims beneficial ownership of the shares reported herein except to the extent of its or his pecuniary interest therein.
Item 5. Ownership of Five Percent or Less of a Class
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [  ].
Item 6. Ownership of More than Five Percent on Behalf of Another Person
Not applicable.
Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company
Not applicable.
Item 8. Identification and Classification of Members of the Group
Not applicable.
Item 9. Notice of Dissolution of Group
Not applicable.
Item 10. Certification
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

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Page 8 of 8 SEC Filing

SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this Statement is true, complete and correct.
February 26, 2016
CORMORANT GLOBAL HEALTHCARE MASTER FUND, LP
By: Cormorant Global Healthcare GP, LLC
 its General Partner
By: /s/ Bihua Chen
Bihua Chen, Managing Member
CORMORANT GLOBAL HEALTHCARE GP, LLC
By: /s/ Bihua Chen
Bihua Chen, Managing Member
CORMORANT ASSET MANAGEMENT, LLC
By: /s/ Bihua Chen
Bihua Chen, Managing Member
/s/ Bihua Chen
Bihua Chen

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