13 Best Major Stocks to Invest in Now

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1. Intuitive Surgical, Inc. (NASDAQ:ISRG)

Number of Hedge Fund Holders: 106 

Intuitive Surgical, Inc. (NASDAQ:ISRG) tops our list for being one of the best major stocks. It is known for its da Vinci robotic surgical systems and reported strong Q2 2025 results, highlighting continued growth and innovation in minimally invasive surgery. Revenue rose 21% year-over-year to $2.44 billion, driven by a 17% increase in procedure volumes and record placements of 395 da Vinci systems globally. Of these, 180 were the newer da Vinci 5 systems, up from 70 a year earlier. The total installed base expanded to 10,488 systems, a 14% increase.

The da Vinci 5 rollout is central to the company’s momentum. It recently received EU certification for adult and pediatric procedures across multiple specialties, and clearance in Japan for nearly all previously approved surgical areas, excluding cardiac. Additional approval for the system’s force feedback technology is being pursued in Europe.

Intuitive Surgical, Inc. (NASDAQ:ISRG) updated its 2025 gross margin outlook to 66%, adjusting for tariff effects. The company also reaffirmed expectations for 15–17% global procedure growth this year, reflecting strong demand as hospitals address surgical backlogs and broaden access to robotic procedures.

While we acknowledge the potential of ISRG to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than ISRG and that has 100x upside potential, check out our report about this cheapest AI stock.

READ NEXT: 30 Stocks That Should Double in 3 Years and 11 Hidden AI Stocks to Buy Right Now.

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