In this article, we will look at the 12 Most Profitable Blue Chip Stocks to Invest In Now.
On March 12, Stephen Parker, JPMorgan Private Bank co-head of global investment strategy, appeared on CNBC’s ‘Squawk Box’ to talk about the latest market trends and the effects of the Iran war. He stated that he has consistently maintained that geopolitical events rarely have long-lasting impacts on markets. However, at the same time, it is important to recognise that they do have the potential to cause short-term disruptions, especially if energy markets are at the center of the storm, as they are right now.
READ ALSO: 15 Best Penny Stocks to Buy According to Reddit AND 12 Best Stocks That Will Always Grow.
He summarized the three primary things he is saying to clients, the first of which is staying diversified and disciplined, as diversification is back in vogue, and it continues to work. Secondly, he urged investors to think about looking for opportunities amidst volatility; option strategies that can give one some downside protection. The third point was to start building your shopping list, because to the extent we have seen more volatility in the near term, there are going to be really interesting fundamental stories that one is going to want to begin to phase into in portfolios.
Parker was also of the view that the market is currently pricing in a short-lived oil shock, with little medium-term impact anticipated. Recent oil price spikes suggest expectations for a pullback instead of a protracted disruption.
With these trends in view, let’s look at the most profitable blue-chip stocks to invest in now.
Our Methodology
We used stock screeners and holdings of blue-chip ETFs to make a list of profitable blue-chip stocks with the highest TTM net income and net income margins. We then picked 12 stocks with the highest number of hedge fund holders, as of Q3 2025. We sourced the hedge fund sentiment data from Insider Monkey’s database. The list is sorted in ascending order of hedge fund holders.
Note: All data was recorded on March 12.
Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 498.7% since May 2014, beating its benchmark by 303 percentage points (see more details here).
12 Most Profitable Blue Chip Stocks to Invest In Now
12. AstraZeneca PLC (NASDAQ:AZN)
AstraZeneca PLC (NASDAQ:AZN) is one of the most profitable blue chip stocks to invest in now. Guggenheim lifted the price target on AstraZeneca PLC (NASDAQ:AZN) to 16,000 GBp from 15,500 GBp on March 10, reiterating a Buy rating on the shares and telling investors that it is updating its model after the company’s fiscal 2025 results and follow-up presentations at several investor conferences.
The rating update came after the company announced on March 9 that AstraZeneca PLC (NASDAQ:AZN) and Daiichi Sankyo’s supplemental Biologics License Application for Enhertu has been accepted and granted Priority Review in the US by the Food and Drug Administration (FDA) for the treatment of adult patients with HER2-positive breast cancer who have residual invasive disease after neoadjuvant HER2-targeted treatment.
It reported that the FDA grants Priority Review to applications for medicines that, upon their approval, have the potential to offer considerable improvements over the available treatment options by exhibiting safety or efficacy improvements, boosting patient compliance, or preventing serious conditions. AstraZeneca PLC (NASDAQ:AZN) stated that the Prescription Drug User Fee Act date, the FDA action date for its regulatory decision, is expected during the third quarter of 2026.
AstraZeneca PLC (NASDAQ:AZN) is a biopharmaceutical company that explores, develops, manufactures, and commercializes prescription medicines. It supplies its products and services to specialty and primary care physicians, and is involved in exploring novel immuno-oncology treatment approaches. AstraZeneca PLC (NASDAQ:AZN) distributes its products and services through local representative offices and distributors.
11. Johnson & Johnson (NYSE:JNJ)
Johnson & Johnson (NYSE:JNJ) is one of the most profitable blue chip stocks to invest in now. On March 11, Citi lifted the price target on Johnson & Johnson (NYSE:JNJ) to $274 from $250 while maintaining a Buy rating on the shares. The firm told investors in a research note that it adjusted price targets in the medical technology group after the release of the fiscal Q4 reports, adding that despite the recent volatility, sector fundamentals remain “healthy”. Citi also stated that its top picks are iRhythm and Medtronic.
In a separate development, Johnson & Johnson (NYSE:JNJ) announced on March 10 the submission of a Type II variation application to the European Medicines Agency (EMA) seeking approval for an indication extension of TECVAYLI® as monotherapy to treat adult patients with relapsed/refractory multiple myeloma who have received at least one prior therapy.
Johnson & Johnson (NYSE:JNJ) further reported that the data from the Phase 3 MajesTEC-9 trial support the submission, which evaluates the safety and efficacy of teclistamab compared to the standard of care of pomalidomide, bortezomib, and dexamethasone or carfilzomib and dexamethasone in 614 patients with RRMM.
Johnson & Johnson (NYSE:JNJ) develops, manufactures, and sells products in the healthcare field. The company operates through two segments: Innovative Medicine and MedTech. The Innovative Medicine segment focuses on various therapeutic areas, including oncology, infectious diseases, immunology, cardiovascular and metabolic diseases, and others. The MedTech segment includes an elaborate range of medical devices and products used in cardiovascular intervention, orthopedics, interventional solutions, surgery, and vision fields.
10. Oracle Corporation (NYSE:ORCL)
Oracle Corporation (NYSE:ORCL) is one of the most profitable blue chip stocks to invest in now. Stifel cut the price target on Oracle Corporation (NYSE:ORCL) to $220 from $275 on March 11, maintaining a Buy rating on the share. The firm told investors in a post-earnings note that while it expects capex growth in FY27 to $75 billion, it also believes that factors such as accelerating IaaS growth stemming from AI and multi-database cloud, and sustained momentum in SaaS apps, should pave the way to better EPS growth rates in FY27.
The rating update came after Oracle Corporation (NYSE:ORCL) reported its fiscal Q3 2026 financial results on March 10, stating that total revenue for the quarter rose to $17.2 billion, up 22% in USD and up 18% in constant currency. GAAP Earnings per Share for the quarter also grew 24% to $1.27, while non-GAAP Earnings per Share rose 21% to $1.79. In addition, the remaining performance obligations for Q3 were $553 billion, up 325% year-over-year in USD.
Oracle Corporation (NYSE:ORCL) provides products and services addressing aspects of corporate IT environments, including applications and infrastructure technologies. The company’s operations are divided into the following business segments: Cloud and License, Hardware, and Services.
9. Walmart Inc. (NASDAQ:WMT)
Walmart Inc. (NASDAQ:WMT) is one of the most profitable blue chip stocks to invest in now. On March 9, Reuters reported Walmart Inc.’s (NASDAQ:WMT) announcement that its Indian e-commerce firm Flipkart shifted its holding company to India from Singapore, paving the way to its planned stock market listing in the country. Flipkart said in a statement that it has attained approval from the Indian government for its internal restructuring and has now completed its “redomiciliation” to India, calling it “a significant milestone”. Reuters also stated that the company aims to list in Mumbai before March 2027.
In a separate development, The Information reported on March 4 that OpenAI is scaling back its plan aimed at introducing direct shopping inside ChatGPT. Following this release, BofA said on March 6 that it views the OpenAI news as a net positive for Walmart Inc. (NASDAQ:WMT). The firm reiterated a Buy rating on Walmart Inc. (NYSE:WMT) with a $150 price target on the shares, and stated that the change has the potential to bring about an integrated commerce solution resembling the company’s previously announced partnership with Google’s Gemini in January.
Walmart Inc. (NASDAQ:WMT) is an omnichannel retailer operating retail and wholesale stores, clubs, e-commerce websites, and mobile applications. It offers an elaborate array of items, from general merchandise and electronics to food, groceries, and more.
8. Eli Lilly and Company (NYSE:LLY)
Eli Lilly and Company (NYSE:LLY) is one of the most profitable blue chip stocks to invest in now. Reuters reported on March 11 that Eli Lilly and Company (NYSE:LLY) plans to invest $3 billion in China over the next decade, helping develop production capacity for its experimental type-2 diabetes and obesity treatment orforglipron. In a statement delivered on WeChat, the company stated that it submitted a marketing application for orforglipron to China’s drug regulator at the end of 2025. It also plans to establish a localised manufacturing and supply system for oral solid dosage forms, according to the statement.
Reuters provided additional context, stating that Eli Lilly and Company (NYSE:LLY) is the latest Western healthcare firm to announce additional manufacturing investment plans in China, following others, such as Haleon, earlier this year. However, not all drugmakers are following this path, as Bristol Myers Squibb announced on September the signing of an agreement to sell its 60% ownership stake in a pharmaceutical joint venture in China, with a manufacturing facility in Shanghai part of the venture.
Eli Lilly and Company (NYSE:LLY) develops, manufactures, discovers, and sells pharmaceutical products. These products span oncology, diabetes, immunology, neuroscience, and other therapies.
7. Tesla, Inc. (NASDAQ:TSLA)
Tesla, Inc. (NASDAQ:TSLA) is one of the most profitable blue chip stocks to invest in now. On March 11, Reuters reported that Elon Musk unmasked a joint project between Tesla, Inc. (NASDAQ:TSLA) and his artificial intelligence startup xAI, which he called “Macrohard” or “Digital Optimus”. Musk stated that it was a system capable of emulating the functions of software companies, and said in a post on his social media platform X that the project pairs xAI’s Grok large language model with a Tesla-developed AI agent that processes real-time computer screen video and keyboard and mouse actions. The Grok large language model takes on the role of a high-level “navigator”. The announcement came after Tesla, Inc. (NASDAQ:TSLA) announced an agreement to invest around $2 billion to acquire shares in xAI in January.
Reuters further reported that investors are already spooked by the launch of Anthropic’s Claude Cowork, fearing disruption by agentic AI to established business models, as Claude Cowork is capable of performing several computer-based tasks autonomously. Musk stated that:
“In principle, it is capable of emulating the function of entire companies. That is why the program is called MACROHARD, a funny reference to Microsoft”.
Tesla, Inc. (NASDAQ:TSLA) designs, manufactures, and sells high-performance electric vehicles and energy generation and storage systems. It operates through two segments: energy generation and storage and automotive. However, the company isn’t merely an automotive manufacturer; investors regard it as a technology company due to its other projects, most of which feature AI.
6. Broadcom Inc. (NASDAQ:AVGO)
Broadcom Inc. (NASDAQ:AVGO) is one of the most profitable blue chip stocks to invest in now. Broadcom Inc. (NASDAQ:AVGO) announced on March 11 the availability of the Taurus™ BCM83640, its 3nm 400G/lane optical PAM-4 DSP, optimized for 1.6T transceiver solutions with unprecedented bandwidth density and efficiency. It stated that the device features 400G/lane serial optical interfaces, which allow optical transceiver manufacturers to deliver low-power 1.6T pluggable modules cost-effectively to meet the growing bandwidth needs for AI data centers.
Vijay Janapaty, vice president and general manager of Broadcom Inc.’s (NASDAQ:AVGO) Physical Layer Products Division, stated that the company’s 400G/lane Taurus platform of optical DSPs is building the foundation for next-generation AI networks and data center connectivity, adding that Taurus is the first 1.6T DSP based on 400G/lane I/O of the industry and “doubles the throughput per lane to enable the next generation of 3.2T optical modules”. It also “pushes the IMDD technology envelope into 400G/lane”, further bringing power down and advancing the company’s plans of cost-optimized solutions for connectivity in AI and cloud networks.
Broadcom Inc. (NASDAQ:AVGO) is a leading multinational technology company specializing in semiconductor and infrastructure software products. Its semiconductor and semiconductor-based solutions serve markets across networking connectivity, broadband, servers and storage systems, wireless device connectivity, and industrial. The company’s infrastructure software solutions serve markets including cybersecurity, private cloud, mainframe software, enterprise software, and Fibre Channel storage area network management.
While we acknowledge the potential of AVGO to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than AVGO and that has 100x upside potential, check out our report about this cheapest AI stock.
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