Galena Biopharma Inc (GALE), Teva Pharmaceutical Industries Ltd (ADR) (TEVA): Could This Breast Cancer Vaccine Be a Game Changer?

Page 1 of 2

Breast cancer claims more than 40,000 lives in the United States annually and is one of the leading causes of death for females globally. However, every year biotech companies are making incredible advances in breast cancer treatments that could eventually eradicate this debilitating disease.

A breast cancer vaccine

One of the most promising new treatments is Galena Biopharma Inc (NASDAQ:GALE)‘s NeuVax, a breast cancer vaccine that attempts to stop recurrences of node-positive HER2-negative breast cancer. NeuVax works by stimulating the patient’s immune system to seek out and destroy residual cancer cells expressing the HER2/neu protein in patients who have achieved remission. The HER2/neu protein is often associated with colon, breast, ovarian, pancreatic, and bladder cancers.

Galena Biopharma Inc

HER2-negative breast cancer accounts for approximately 75% of all breast cancer cases. There is a 15% to 20% chance of breast cancer recurring, even following a mastectomy, which means that NeuVax could be a game-changing blockbuster treatment if approved. In phase 2 trials, patients dosed with the treatment showed a 5.6% recurrence rate compared to a 25.9% recurrence rate in the control arm — a 78.4% reduction in total recurrences.

Two major supporters

NeuVax is currently in a phase 3 trial for the stand-alone usage as a breast cancer vaccine, and in a phase 2 trial for combined use with Roche Holding Ltd. (ADR) (OTCBB:RHHBY)‘s Herceptin. Herceptin is one of the primary approved treatments for HER2 breast cancer, which generated $6 billion in sales last year.

Herceptin is a monoclonal antibody that attaches itself to the surface of a cancer cell to prevent it from receiving new growth signals. It can also alert the immune system to destroy the cancer cells to which it is attached. Therefore, using NeuVax’s ability to stimulate the immune system to actively seek out the cancer with Herceptin’s ability to starve and mark cancer cells could prove to be an incredibly potent combination. For Roche Holding Ltd. (ADR) (OTCBB:RHHBY), creating a new combined treatment could also soften the blow of Herceptin’s upcoming patent expiration in 2014.

In addition to Roche, another major company that believes in Galena Biopharma Inc (NASDAQ:GALE) is Teva Pharmaceutical Industries Ltd (ADR) (NYSE:TEVA). Last December, Galena signed an agreement with Teva to commercialize NeuVax in Israel. Teva will provide marketing support and help NeuVax obtain regulatory approval in the region. Teva Pharmaceutical Industries Ltd (ADR) (NYSE:TEVA) also produces a generic version of AstraZeneca‘s breast cancer drug Arimidex, which is used for post-surgery treatment.

Abstral provides a steady revenue stream

Galena Biopharma Inc (NASDAQ:GALE) also acquired the U.S. commercialization rights for Abstral, a cancer pain medication, from Orexo AB in March. Abstral was approved by the FDA in 2011 as the first and only fentanyl sublingual tablet to treat patients with breakthrough (“spiking”) cancer pain in opioid tolerant patients, and generated $54 million in sales in Europe last year.

Bringing Abstral to the U.S. market will give the company a steady stream of revenue — a strength that many other speculative biotechs sorely lack. Last quarter, Galena Biopharma Inc (NASDAQ:GALE) only had $26.7 million in cash and equivalents, with $9.7 million in debt and a negative cash flow of $21.8 million.

Page 1 of 2
blog comments powered by Disqus
Insider Monkey Headlines
Insider Monkey Small Cap Strategy
Insider Monkey Small Cap Strategy

Insider Monkey beat the market by 52 percentage points in 24 months Click to see monthly returns in table format!

Lists

10 Best States To Practice Medicine

The 10 Best States to Have a Business

The 12 Most Expensive Apple (AAPL) Apps in the Market

The 10 Richest Billionaires in the World

10 Biggest Kickstarter Failures

The 10 Best Places to Work At

The Top 10 of Google Inc (GOOGL)’s Most Expensive Acquisitions

13 Best Cities to Visit in South America

10 Most Expensive Works of Art of All Time

The 10 Richest Banks in the World

The 10 Best-Paying Jobs in America (2014)

7 Most Expensive Foods in the World

The World’s Top 10 Earning Authors

Five Wicked and Very Expensive Items (and Other “Stuff”) Sold on eBay

10 Biggest Celebrity Bankruptcies

The Top 10 Highest Paid CEOs in 2014

The 10 Most Expensive Real Estate Cities in America

10 Most Expensive States To Live In America

The 10 Best Airlines in the World

The 10 Best-Selling Cars in 2014

The 10 Best Industries to Invest In

The 10 Most Expensive States to Own a Car In

Top 10 Business Schools in US: 2014 Rankings

Top 20 Female Billionaires in 2014

6 Movies That You Should Watch to Better Understand The Cold War

Top 15 Best Paying Jobs for Women in 2014

Top 6 Things Rich People Do Differently Every Day

5 Retirement Mistakes To Avoid (and Einstein’s Famous Quote)

11 Smartest People in the World

6 Films About the Financial World You Need To Watch (While “The Wolf” is Not Around)

Warren Buffett and Billionaires Are Crazy About These 7 Stocks

The Top 10 States With Fastest Internet Speeds

10 Best Places to Visit in USA in August

Top 10 Cities to Visit Before You Die

Top 10 Genetically Modified Food In the US

15 Highest Grossing Movies Opening Weekend

5 Best Poker Books For Beginners

10 Strategies Hedge Funds Use to Make Huge Returns

Top 10 Fast Food Franchises to Buy

10 Best Places to Visit in Canada

Best Summer Jobs for Teachers

10 Youngest Hedge Fund Billionaires

Top 10 One Hit Wonders of the 90s

Fastest Growing Cities In America

Top 10 U.S. Cities for Freelancers

Top 9 Most Popular Free iPhone Apps

Top 10 Least Expensive Private Business Schools in the US

Top 15 Most Expensive Countries in the World – 2014

Top 6 Tax Scams and How to Protect Yourself

Top Businesses to Invest In

Subscribe

Enter your email:

Delivered by FeedBurner

X

Thanks! An email with instructions is sent to !

Your email already exists in our database. Click here to go to your subscriptions

Insider Monkey returned 47.6% in its first year! Wondering How?

Download a complete edition of our newsletter for free!