| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 10,909,256 | $15,709,329 | 0.37% | |
| 2. | Baker Bros. Advisors Julian Baker And Felix Baker | 10,123,824 | $14,578,307 | 0.11% | |
| 3. | Millennium Management Israel Englander | 1,147,044 | $1,651,743 | +362% | 0% |
| 4. | Renaissance Technologies Jim Simons | 544,000 | $783,360 | -7% | 0% |
| 5. | Two Sigma Advisors John Overdeck And David Siegel | 222,700 | $320,688 | -2% | 0% |