| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | DAFNA Capital Management Nathan Fischel | 432,830 | $991 | 0.37% | |
| 2. | Frazier Healthcare Partners Alan Frazier | 282,649 | $647 | -68% | 0.2% |
| 3. | Deerfield Management James E. Flynn | 1,107,643 | $2,537 | 0.1% | |
| 4. | OrbiMed Advisors Samuel Isaly | 2,029,996 | $4,649 | 0.08% | |
| 5. | Perceptive Advisors Joseph Edelman | 0 | $0 | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $7.00 | 714,285 | Large Shareholder | 2,253,509 | 2015-10-06 | Filing | |
| $7.00 | 857,142 | Large Shareholder | 2,974,811 | 2015-10-06 | Filing | |
| $7.00 | 857,142 | Large Shareholder | 2,971,517 | 2015-10-06 | Filing | |
| $7.00 | 857,142 | Large Shareholder | 2,971,517 | 2015-10-06 | Filing | |
| $7.00 | 857,142 | Large Shareholder | 2,971,517 | 2015-10-06 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $9.75 | 5,849 | Officer | 48,135 | 2019-02-13 | Filing | |
| $9.75 | 3,151 | Officer | 53,984 | 2019-02-12 | Filing | |
| $9.77 | 3,000 | Officer | 57,135 | 2018-10-18 | Filing | |
| $13.05 | 3,000 | Officer | 60,135 | 2018-09-18 | Filing | |
| $12.55 | 3,000 | Officer | 63,135 | 2018-09-05 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 2,651,963 | $6,073 | 9.99% | |
| 2. | 70,363 | $161 | 0.12% | |
| 3. | 34,297 | $79 | 0% | |
| 4. | 23,573 | $54 | 0% | |
| 5. | 14,844 | $34 | 0% |
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