| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Darwin Global Management Abhishek Trehan | 20,457,445 | $2,897,797,084 | +6% | 80.54% |
| 2. | Baker Bros. Advisors Julian Baker And Felix Baker | 6,703,484 | $965,368,731 | -14% | 6.98% |
| 3. | D E Shaw D. E. Shaw | 5,657,464 | $814,731,390 | +66% | 0.46% |
| 4. | Orbis Investment Management William B. Gray | 3,250,868 | $468,157,501 | +114% | 2.01% |
| 5. | Millennium Management Israel Englander | 2,336,112 | $336,423,489 | +11% | 0.14% |