| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Bridger Management Roberto Mignone | 4,773,718 | $69,935 | 5.53% | |
| 2. | EcoR1 Capital Oleg Nodelman | 3,316,407 | $48,585 | 4.47% | |
| 3. | Sio Capital Michael Castor | 766,980 | $11,236 | +73% | 3.03% |
| 4. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,400,956 | $20,524 | +16% | 2.29% |
| 5. | RA Capital Management Peter Kolchinsky | 2,456,669 | $35,990 | 1.55% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $7.00 | 285,000 | Large Shareholder, Director | 285,000 | 2017-12-18 | Filing | |
| $3.63 | 16,500 | Officer, Director | 55,579 | 2016-11-15 | Filing | |
| $3.78 | 16,600 | Officer, Director | 39,079 | 2016-11-14 | Filing | |
| $3.29 | 4,170 | Officer | 19,800 | 2016-05-12 | Filing | |
| $3.29 | 530 | Officer | 15,630 | 2016-05-12 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $12.50 | 1,600,000 | Large Shareholder, Director | 7,330,237 | 2019-05-29 | Filing | |
| $15.00 | 15,000 | Officer | 24,480 | 2019-04-02 | Filing | |
| $14.16 | 11 | Director | 19,150 | 2018-11-06 | Filing | |
| $14.16 | 1,489 | Director | 2,586,535 | 2018-11-06 | Filing | |
| $13.18 | 761 | Director | 19,161 | 2018-11-06 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 8,930,237 | $130,828 | 52.3% | |
| 2. | 6,223,036 | $91,167 | 6.22% | |
| 3. | 328,825 | $4,817 | 2.29% | |
| 4. | 167,157 | $2,449 | 0.78% | |
| 5. | 241,113 | $3,532 | 0.78% |
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