| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | RA Capital Management Peter Kolchinsky | 7,266,031 | $206,355,280 | +16% | 3.48% |
| 2. | VenBio Select Advisor Kurt Von Emster | 7,050,000 | $200,220,000 | -8% | 3.51% |
| 3. | OrbiMed Advisors Samuel Isaly | 1,812,886 | $51,485,962 | 1.29% | |
| 4. | Casdin Capital Eli Casdin | 1,775,000 | $50,410,000 | -14% | 4.59% |
| 5. | Polar Capital Brian Ashford-Russell And Tim Woolley | 1,770,387 | $50,278,991 | -2% | 0.26% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $18.00 | 800,000 | $14,400,000.00 | 4,795,000 | 2021-08-04 | Filing | |
| $18.00 | 300,000 | $5,400,000.00 | 2,514,545 | 2020-06-16 | Filing | |
| $18.00 | 950,000 | $17,100,000.00 | 3,995,000 | 2020-06-16 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $46.56 | 10,000 | $465,632.00 | 97,130 | 2025-08-15 | Filing | |
| $42.73 | 30,914 | $1,320,843.93 | 65,806 | 2025-08-06 | Filing | |
| $46.66 | 1,542 | $71,949.72 | 38,867 | 2025-08-13 | Filing | |
| $44.06 | 6,120 | $269,663.11 | 55,000 | 2025-08-06 | Filing | |
| $44.06 | 124,687 | $5,494,033.41 | 61,120 | 2025-08-06 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 16,185,791 | $459,676,463 | 0.03% | |
| 2. | 10,777,317 | $306,055,934 | 0.15% | |
| 3. | 9,618,845 | $273,175,198 | 3.89% | |
| 4. | 9,336,834 | $265,166,084 | 0.01% | |
| 5. | 9,249,690 | $262,691,197 | 0.05% |
