| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | RA Capital Management Peter Kolchinsky | 8,641,031 | $376,489,721 | +19% | 4.64% |
| 2. | VenBio Select Advisor Kurt Von Emster | 7,645,000 | $333,092,650 | +9% | 4.31% |
| 3. | Polar Capital Brian Ashford-Russell And Tim Woolley | 2,796,760 | $121,854,833 | +58% | 0.59% |
| 4. | Casdin Capital Eli Casdin | 1,780,000 | $77,554,600 | +1% | 6.47% |
| 5. | OrbiMed Advisors Samuel Isaly | 1,638,886 | $71,406,263 | -10% | 1.68% |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $18.00 | 800,000 | $14,400,000.00 | 4,795,000 | 2021-08-04 | Filing | |
| $18.00 | 300,000 | $5,400,000.00 | 2,514,545 | 2020-06-16 | Filing | |
| $18.00 | 950,000 | $17,100,000.00 | 3,995,000 | 2020-06-16 | Filing |
| Insider | Price | Amount | Total Value | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $47.54 | 2,209 | $105,014.53 | 38,867 | 2025-10-22 | Filing | |
| $50.15 | 20,000 | $1,003,058.00 | 97,130 | 2025-10-15 | Filing | |
| $45.38 | 6,562 | $297,771.09 | 55,000 | 2025-10-03 | Filing | |
| $40.58 | 2,208 | $89,600.64 | 38,867 | 2025-09-22 | Filing | |
| $41.41 | 15,000 | $621,142.50 | 97,130 | 2025-09-15 | Filing |
| No. | Name | Shares | Value | % Port |
|---|---|---|---|---|
| 1. | 21,585,984 | $940,501,305 | 0.05% | |
| 2. | 14,522,915 | $632,808,722 | 0.29% | |
| 3. | 13,219,759 | $575,984,899 | 0.01% | |
| 4. | 11,372,829 | $495,514,160 | 6.11% | |
| 5. | 10,065,187 | $438,540,198 | 0.08% |