| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Biotechnology Value Fund / BVF Inc Mark Lampert | 1,355,256 | $17,225,304 | +32% | 0.7% |
| 2. | OrbiMed Advisors Samuel Isaly | 1,349,300 | $17,149,603 | +40% | 0.4% |
| 3. | Nantahala Capital Management Wilmot B. Harkey And Daniel Mack | 1,235,000 | $15,696,850 | +25% | 0.55% |
| 4. | Point72 Asset Management Steve Cohen | 1,053,983 | $13,396,124 | 0.02% | |
| 5. | Caligan Partners David Johnson | 833,333 | $10,591,662 | 1.39% |