| No. | Hedge Fund | Shares | Value (x$1000) | Activity | % Port |
|---|---|---|---|---|---|
| 1. | Harvard Management Co Jane Mendillo | 640,595 | $4,708 | 1.2% | |
| 2. | Biotechnology Value Fund / BVF Inc Mark Lampert | 287,776 | $2,115 | -3% | 0.18% |
| 3. | Sectoral Asset Management Jerome Pfund And Michael Sjostrom | 18,921 | $139 | 0.01% | |
| 4. | Millennium Management Israel Englander | 93,066 | $684 | +131% | 0% |
| 5. | Two Sigma Advisors John Overdeck And David Siegel | 33,000 | $243 | -10% | 0% |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $17.00 | 7,500 | Large Shareholder | 33,649 | 2015-04-20 | Filing | |
| $17.00 | 10,000 | Large Shareholder | 36,149 | 2015-04-20 | Filing | |
| $17.00 | 147,058 | Large Shareholder | 5,991,759 | 2015-04-20 | Filing | |
| $17.00 | 441,176 | Large Shareholder | 19,043,518 | 2015-04-20 | Filing | |
| $17.00 | 1,700 | Director | 1,700 | 2015-04-20 | Filing |
| Insider | Price | Amount | Relationship | Remaining Holdings | Date | Form 4 |
|---|---|---|---|---|---|---|
| $2.57 | 1,907 | Officer | 252,482 | 2018-12-28 | Filing | |
| $2.93 | 1,035 | Officer | 135,155 | 2018-12-12 | Filing | |
| $2.93 | 1,241 | Officer | 129,878 | 2018-12-12 | Filing | |
| $2.93 | 5,829 | Officer, Director | 327,024 | 2018-12-12 | Filing | |
| $2.93 | 2,171 | Officer | 254,389 | 2018-12-12 | Filing |
| No. | Name | Shares | Value (x$1000) | % Port |
|---|---|---|---|---|
| 1. | 1,500 | $4 | 0% | |
| 2. | 1,127 | $3 | 0% | |
| 3. | 0 | $0 | 0% | |
| 4. | 1 | $0 | 0% | |
| 5. | 14,236 | $38 | 0% |
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