| No. | Hedge Fund | Shares | Value | Activity | % Port |
|---|---|---|---|---|---|
| 1. | OrbiMed Advisors Samuel Isaly | 11,447,140 | $9,274,473 | 0.22% | |
| 2. | Tang Capital Management Kevin C. Tang | 8,223,612 | $6,662,770 | 0.26% | |
| 3. | RA Capital Management Peter Kolchinsky | 7,541,000 | $6,109,718 | 0.08% | |
| 4. | Renaissance Technologies Jim Simons | 1,828,949 | $1,481,814 | +59% | 0% |
| 5. | Two Sigma Advisors John Overdeck And David Siegel | 780,982 | $632,752 | +38% | 0% |