Top 5 Most Profitable Pharmaceutical Companies In The World

4. Pfizer Inc. (NYSE:PFE)

2022 Net Income: $31.4 billion

2022 Revenue: $100.33 billion

Pfizer Inc. (NYSE:PFE) dominated the drugmaker revenue charts in 2022 with a record-breaking $100.3 billion and stands fourth among the top most profitable pharmaceutical companies in the world. The mRNA COVID vaccine, Comirnaty, brought in $37.8 billion, and Paxlovid generated $18.9 billion. Pfizer has yet to announce vaccine prices in the commercial market, but they may be around $110 to $130 per dose. Pfizer Inc. (NYSE:PFE) was criticized for its pricing scheme, but the possible prices align with other vaccines. The company also faced litigation over Zantac’s cancer-causing potential, with some cases dismissed, and settlements reached with Sanofi.