Top 5 Drug Companies in the US by Revenue

4. AbbVie Inc. (NYSE:ABBV)

2022 Revenue: $58.1 billion

AbbVie Inc. (NYSE:ABBV), with a business presence in more than 70 countries, is considered to be among the biggest drug companies not only in the United States but also globally. It develops medicine for fighting cancers, cystic fibrosis, neurological diseases, and eye ailments.

The company sells a variety of well-known drugs, such as Humira (one of the most profitable drugs in the world), Venclexta, Imbruvica, and Skyrizi.