Top 11 Small Cap Stocks to Buy with Biggest Upside Potential

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1. Bicycle Therapeutics plc (NASDAQ:BCYC)

Market Cap: $627.08 million

Analyst Upside: 244.63%

Number of Hedge Fund Holders: 23

Bicycle Therapeutics plc (NASDAQ:BCYC) is a clinical-stage biopharmaceutical company that develops a novel medicine class, which it calls bicycles, for the treatment of diseases underserved by existing therapies. Its product portfolio includes internal product candidates directed to oncology applications.

Analyst Swayampakula Ramakanth from H.C. Wainwright maintained a Buy rating on Bicycle Therapeutics plc (NASDAQ:BCYC) on April 1, keeping the price target at $33.00. The analyst said that the company has a solid financial position and promising advancements. It has made notable progress in its pipeline, especially in its MT1-MMP-targeting Bicycle Radioconjugates (BRC), which has reflected promising results in cancer imaging and validated MT1-MMP as a potential marker for various cancers. The analyst opined that this progress supports further optimization and development of their BRCs for cancer diagnosis.

Bicycle Therapeutics plc (NASDAQ:BCYC) also has considerable cash reserves of $793 million, which can provide a clear financial pathway till H2 2027. The company is thus in a strong financial position to advance its Nectin-4 BTC program and achieve multiple clinical milestones.

Overall, BCYC ranks first among the top small-cap stocks to buy with the biggest upside potential. While we acknowledge the potential of small-cap stocks, our conviction lies in the belief that AI stocks hold greater promise for delivering higher returns and doing so within a shorter time frame. There is an AI stock that went up since the beginning of 2025, while popular AI stocks lost around 25%. If you are looking for an AI stock that is more promising than BCYC but that trades at less than 5 times its earnings, check out our report about this cheapest AI stock.

READ NEXT: 20 Best AI Stocks To Buy Now and 30 Best Stocks to Buy Now According to Billionaires.

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