Syros Pharmaceuticals (SYRS): Deerfield Management Discloses Position

CUSIP No.

87184Q107

13G

Page 9 of 11

(g)

o

A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G);


(h)		o	A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act;


(i)		o	A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act;


(j)		o	A non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J);

(k)

o

Group, in accordance with Rule 13d-1(b)(1)(ii)(K).

If filing as a non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J), please specify the type of institution: _________________

Item 4.

Ownership.

Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.

(a)			Amount beneficially owned**:

			Deerfield Mgmt, L.P. – 628,566 shares Deerfield Mgmt III, L.P. – 1,466,654 shares Deerfield Management Company, L.P. – 2,095,220 shares Deerfield Special Situations Fund, L.P. – 628,566 shares Deerfield Private Design Fund III, L.P. – 1,466,654 shares James E. Flynn – 2,095,220 shares

(b)			Percent of class**:

			Deerfield Mgmt, L.P. – 2.69% Deerfield Mgmt III, L.P. – 6.28% Deerfield Management Company, L.P. – 8.97% Deerfield Special Situations Fund, L.P. – 2.69% Deerfield Private Design Fund III, L.P. – 6.28% James E. Flynn – 8.97%

(c)	Number of shares as to which such person has**:

	(i)	Sole power to vote or to direct the vote:	All Reporting Persons – 0

	(ii)	Shared power to vote or to direct the vote:	Deerfield Mgmt, L.P. – 628,566 shares Deerfield Mgmt III, L.P. – 1,466,654 shares Deerfield Management Company, L.P. – 2,095,220 shares Deerfield Special Situations Fund, L.P. – 628,566 shares Deerfield Private Design Fund III, L.P. – 1,466,654 shares James E. Flynn – 2,095,220 shares

The $250 Trillion AI Hype is Real. A few years from now, you’ll probably wish you’d bought this stock.


(f)	o	An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F);