Importantly some of those biomarker data over the second part for PIVOT-HD that we will present with the 12-month data cut later once available. And that will confirm if we are at the dose level we want. And then we’ll probably use that time point to inform any additional decisions, regarding — going to that higher dose level of 20 milligrams. Of course, it’s important to note that we’re in incredibly stable position with an oral molecule that we can titrate. And to be able to have peripheral biomarkers, such as blood huntingtin protein, that provide important information regarding target engagement and pharmacodynamic effect, is an incredibly important factor in being able to steer this clinical development program forward ,and taking us to a right dose level that’s not only safe, but could provide important benefit potentially for patients.
So, as for now we’re continuing with the five and 10. We will expect to have that next update the biomarker 12-month data update, approximately nine months from when we had the three-month data update. And again, in terms of that decision it will be based on what the data look like. And as I mentioned the DSMB has already provided us their okay and support to go that higher dose, if and when we decide we need to.
Yihan Li: That’s very helpful. So just – sorry, just one quick clarification. So do you — will you provide for example, additional trial-based from Stage two or early Stage three patients in terms of the program, or the next asset will just be the nine months data? Thank you
Matthew Klein: Yes. So, good question. So we have a few more data updates to go, right? So obviously, those first patients that we presented the Part A data or that first three-month data on in June, we will expect in approximately nine months from then to have the 12-month data, right? And then obviously, we’ll be able to provide the 3-month data update on the additional Stage two and the early Stage three patients when those available. We haven’t given that time yet and we will provide the timing for that, once we have more clarity on the precise date.
Yihan Li: Very helpful. Thank you so much.
Operator: Thank you. And one moment for our next question. And our next question comes from Joseph Thome from TD Cowen. Your line is now open
Joseph Thome: Hi, there. good afternoon. Thank you for taking my questions. Maybe one on Upstaza. It seems like companies are having various ability to treat patients after the approval of a gene therapy in the US, and varying success here. So I guess, is there anything you can do during the hopeful update review process to kind of prime payers to be ready to reimburse Upstaza upon potential US approval, which I expect will come sometime in the back half of next year? And then maybe second. We are going to know what the pipeline looks like by the end of this year based on the regulatory feedback you get in the next couple of months. I believe in your previous deal, with Blackstone there was like $500 million earmarked for BD. I guess are you ever contemplating using that at all depending on, what comes up over the next few months? Thank you.
Matthew Klein: Thank you very much for the question. The first question on Upstaza, I’ll let Kylie give some detail on how we’re studying the US market in terms of payers. But I will add that we’re obviously, incredibly gratified with this as we continue treatment in Europe as well as the treatments that we did as part of the Canada study that included sites in the US. We’re continuing to see very strong data again, substantiating the fact that this is a transformative therapy. It’s one of those therapies where we get it and we see the effects that we’re hopeful, with a gene therapy. Taking kids who have virtually no dopamine production, no motor function and then providing an ability to make dopamine and seeing them be able to sit crawl and walk is incredibly gratifying.
