Park West Asset Management Is Betting On Semler Scientific Inc.

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934

(Amendment No.    )*

Check the appropriate box to designate the
rule pursuant to which this Schedule 13G is filed:

[   ] Rule 13d-1(b)

[X] Rule 13d-1(c)

[   ] Rule 13d-1(d)

* The remainder of this cover page shall be
filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for
any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of
this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934
(“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).

* Beneficial ownership percentage
is based upon 6,095,962 shares of common stock, $0.001 par value per share (“Common Stock”), of Semler
Scientific, Inc., a Delaware corporation (the “Company”), issued and outstanding as of August 24, 2018, based on
information reported by the Company in its Definitive Proxy Statement on Schedule 14A, as amended, filed with the Securities
and Exchange Commission on August 31, 2018. Park West Asset Management LLC (“PWAM”) is the investment manager to
Park West Investors Master Fund, Limited, a Cayman Islands exempted company (“PWIMF”), and Park West Partners
International, Limited, a Cayman Islands exempted company (“PWPI” and, collectively with PWIMF, the “PW
Funds”), and Peter S. Park (“Mr. Park” and, collectively with PWAM and PWIMF, the “Reporting
Persons”) is the sole member and manager of PWAM. As of September 13, 2018, PWIMF held 339,517 shares of Common Stock of
the Company and PWPI held 37,563 shares of Common Stock of the Company. As a result of the foregoing, for purposes of Reg.
Section 240.13d-3, PWAM and Mr. Park may be deemed to beneficially own the 377,080 shares of Common Stock of the Company held
in the aggregate by the PW Funds, or approximately 6.2% of the shares of Common Stock of the Company deemed issued and
outstanding as of September 13, 2018.

  * Beneficial ownership percentage
is based upon 6,095,962 shares of Common Stock of the Company issued and outstanding as of August 24, 2018, based on information
reported by the Company in its Definitive Proxy Statement on Schedule 14A, as amended, filed with the Securities and Exchange Commission on
August 31, 2018. As of September 13, 2018, PWIMF held 339,517 shares of Common Stock of the Company, or approximately 5.6% of the
shares of Common Stock of the Company deemed issued and outstanding as of September 13, 2018.

* Beneficial ownership percentage is based
upon 6,095,962 shares of Common Stock of the Company issued and outstanding as of August 24, 2018, based on information reported
by the Company in its Definitive Proxy Statement on Schedule 14A, as amended, filed with the Securities and Exchange Commission on August 31,
2018. PWAM is the investment manager to the PW Funds, and Mr. Park is the sole member and manager of PWAM. As of September 13,
2018, PWIMF held 339,517 shares of Common Stock of the Company and PWPI held 37,563 shares of Common Stock of the Company. As a
result of the foregoing, for purposes of Reg. Section 240.13d-3, PWAM and Mr. Park may be deemed to beneficially own the 377,080
shares of Common Stock of the Company held in the aggregate by the PW Funds, or approximately 6.2% of the shares of Common Stock
of the Company deemed issued and outstanding as of September 13, 2018.

* This Schedule 13G is being jointly filed
by (i) PWAM, a Delaware limited liability company and the investment manager to (a) PWIMF, a Cayman Islands exempted company that
is the holder of 339,517 shares of Common Stock and (b) PWPI, a Cayman Islands exempted company that is the holder of 37,563 shares
of Common Stock of the Company, as reported on this Schedule 13G; (ii) PWIMF; and (iii) Mr. Park, as the sole member and manager
of PWAM.

The 377,080 shares of Common Stock held in the aggregate
by the PW Funds, which constitutes approximately 6.2% of the shares of Common Stock of the Company deemed issued and outstanding
as of September 13, 2018, may be deemed to be beneficially owned (x) indirectly by PWAM, as the investment adviser to PWIMF and
PWPI, and (y) indirectly by Mr. Park, as the sole member and manager of PWAM.

The foregoing beneficial ownership
percentage is based upon 6,095,962 shares of Common Stock of the Company, issued and outstanding as of August 24, 2018, based on
information reported by the Company in its Definitive Proxy Statement on Schedule 14A, as amended, filed with the Securities and Exchange Commission
on August 31, 2018.

SIGNATURE

          After
reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true,
complete and correct.

Attention: Intentional misstatements or omissions
of fact constitute

Federal criminal violations (See 18 U.S.C.
1001)

Exhibit Index