Pacific Biosciences Of California Inc. (PACB): Bridger Management Ups Its Stake

Item 1(a).

Name of Issuer:  Pacific Biosciences of California, Inc.

Item 1(b).

Address of Issuer’s Principal Executive Offices:

1380 Willow Road, Menlo Park, CA 94025

Item 2(a, b, c).

Name of Persons Filing, Address of Principal Business Office, Citizenship:

Bridger Management, LLC, a Delaware limited liability company, 90 Park Avenue – 40^th Floor, New York, NY 10016

Mr. Roberto Mignone (“Mr. Mignone”), 90 Park Avenue – 40^th Floor, New York, NY 10016.  Mr. Mignone is a United States citizen.

Item 2(d).

Title of Class of Securities: Common Stock, par value $0.001 per share (the “Common Stock”)

Item 2(e).

CUSIP Number:  69404D108

Item 3.

Not Applicable.

Item 4.

Ownership.

Information with respect to the Reporting Persons’ ownership of the Common Stock as of April 25, 2016, is incorporated by reference to items (5) – (9) and (11) of the cover page of the respective Reporting Person.

Swiftcurrent Partners L.P., Swiftcurrent Offshore Master, Ltd., and Bridger Healthcare, Ltd. are the owners of record of the Common Stock reported herein.  Bridger Management, LLC is the investment adviser to Swiftcurrent Partners L.P., Swiftcurrent Offshore Master, Ltd., and Bridger Healthcare, Ltd.  Mr. Mignone is the manager of Bridger Management, LLC.  Each of Bridger Management LLC and Mr. Mignone may be deemed to share beneficial ownership of the Common Stock reported herein.

Item 5.

Ownership of Five Percent or less of a Class:

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following [    ].

Item 6.

Ownership of More than Five Percent on Behalf of Another Person.

See Item 4.

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

Not Applicable.

Item 8.

Identification and Classification of Members of the Group.

Not Applicable.

Item 9.

Notice of Dissolution of Group.

Not Applicable.

Item 10.

Certification.

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.