Page 4 of 18 SEC Filing       CUSIP No. 67552A108    Page 4 of 18     
                                         1.         Name of reporting persons   Venrock Healthcare Capital Partners II, L.P.         2.        Check the appropriate box if a member of a group (see instructions) (a)  x1         (b)  ¨           3.        SEC use only           4.        Citizenship or place of organization       Delaware       Number of shares beneficially owned by each reporting person with:          5.           Sole voting power       0             6.          Shared voting power       1,885,6682             7.          Sole dispositive power       0             8.          Shared dispositive power       1,885,6682         9.        Aggregate amount beneficially owned by each reporting person       1,885,6682       10.        Check if the aggregate amount in Row (9) excludes certain shares (see instructions)    ¨         11.        Percent of class represented by amount in Row (9)       9.1%3       12.        Type of reporting person (see instructions)       PN      
         1    Venrock Healthcare Capital Partners, L.P., VHCP Co-Investment Holdings, LLC, Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, VHCP Management, LLC, VHCP Management II, LLC, Bong Koh and Anders Hove are members of a group for the purposes of this Schedule 13G.      
        2    Consists of (i) 792,351 shares of common stock owned by Venrock Healthcare Capital Partners, L.P., including 118,981 shares underlying immediately exercisable warrants; (ii) 144,945 shares of common stock owned by VHCP Co-Investment Holdings, LLC, including 21,765 shares underlying immediately exercisable warrants; (iii) 674,803 shares of common stock owned by Venrock Healthcare Capital Partners II, L.P.; and (iv) 273,569 shares of common stock owned by VHCP Co-Investment Holdings II, LLC.      
        3    This percentage is calculated based upon 20,503,211 shares of common stock outstanding as of October 31, 2015, as set forth in Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.      
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|   CUSIP No. 67552A108   |  Page 4 of 18 | 
|     1.    |    Name of reporting persons  Venrock Healthcare Capital Partners II, L.P.   |  |||||
|     2.   |    Check the appropriate box if a member of a group (see instructions)  (a)  x1         (b)  ¨   |  |||||
|     3.   |    SEC use only   |  |||||
|     4.   |    Citizenship or place of organization      Delaware   |  |||||
|   Number of  shares  beneficially  owned by  each  reporting  person  with:   |    |    5.    |    |    Sole voting power      0   |  ||
|   |    6.   |    |    Shared voting power      1,885,6682   |  |||
|   |    7.   |    |    Sole dispositive power      0   |  |||
|   |    8.   |    |    Shared dispositive power      1,885,6682   |  |||
|     9.   |    Aggregate amount beneficially owned by each reporting person      1,885,6682   |  |||||
|   10.   |    Check if the aggregate amount in Row (9) excludes certain shares (see instructions)    ¨   |  |||||
|   11.   |    Percent of class represented by amount in Row (9)      9.1%3   |  |||||
|   12.   |    Type of reporting person (see instructions)      PN   |  |||||
|   1   |    Venrock Healthcare Capital Partners, L.P., VHCP Co-Investment Holdings, LLC, Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, VHCP Management, LLC, VHCP Management II, LLC, Bong Koh and Anders Hove are members of a group for the purposes of this Schedule 13G.   |  
|   2   |    Consists of (i) 792,351 shares of common stock owned by Venrock Healthcare Capital Partners, L.P., including 118,981 shares underlying immediately exercisable warrants; (ii) 144,945 shares of common stock owned by VHCP Co-Investment Holdings, LLC, including 21,765 shares underlying immediately exercisable warrants; (iii) 674,803 shares of common stock owned by Venrock Healthcare Capital Partners II, L.P.; and (iv) 273,569 shares of common stock owned by VHCP Co-Investment Holdings II, LLC.   |  
|   3   |    This percentage is calculated based upon 20,503,211 shares of common stock outstanding as of October 31, 2015, as set forth in Issuer’s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 5, 2015.   |  
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