Page 11 of 18 SEC Filing CUSIP No. 67552A108 Page 11 of 18
Item 4. Ownership
(a) Amount Beneficially Owned as of March 3, 2016:
Venrock Healthcare Capital Partners, L.P. 1,885,668 (1) VHCP Co-Investment Holdings, LLC 1,885,668 (1) Venrock Healthcare Capital Partners II, L.P. 1,885,668 (1) VHCP Co-Investment Holdings II, LLC 1,885,668 (1) VHCP Management, LLC 1,885,668 (1) VHCP Management II, LLC 1,885,668 (1) Anders Hove 1,885,668 (1) Bong Koh 1,885,668 (1)
(b) Percent of Class as of March 3, 2016:
Venrock Healthcare Capital Partners, L.P. 9.1 % VHCP Co-Investment Holdings, LLC 9.1 % Venrock Healthcare Capital Partners II, L.P. 9.1 % VHCP Co-Investment Holdings II, LLC 9.1 % VHCP Management, LLC 9.1 % VHCP Management II, LLC 9.1 % Anders Hove 9.1 % Bong Koh 9.1 %
(c) Number of shares as to which the person has, as of March 3, 2016:
(i) Sole power to vote or to direct the vote
Venrock Healthcare Capital Partners, L.P. 0 VHCP Co-Investment Holdings, LLC 0 Venrock Healthcare Capital Partners II, L.P. 0 VHCP Co-Investment Holdings II, LLC 0 VHCP Management, LLC 0 VHCP Management II, LLC 0 Anders Hove 0 Bong Koh 0
(ii) Shared power to vote or to direct the vote
Venrock Healthcare Capital Partners, L.P. 1,885,668 (1) VHCP Co-Investment Holdings, LLC 1,885,668 (1) Venrock Healthcare Capital Partners II, L.P. 1,885,668 (1) VHCP Co-Investment Holdings II, LLC 1,885,668 (1) VHCP Management, LLC 1,885,668 (1) VHCP Management II, LLC 1,885,668 (1) Anders Hove 1,885,668 (1) Bong Koh 1,885,668 (1)
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| CUSIP No. 67552A108 | Page 11 of 18 |
| Item 4. | Ownership |
| (a) | Amount Beneficially Owned as of March 3, 2016: |
| Venrock Healthcare Capital Partners, L.P. | 1,885,668 | (1) | ||
| VHCP Co-Investment Holdings, LLC | 1,885,668 | (1) | ||
| Venrock Healthcare Capital Partners II, L.P. | 1,885,668 | (1) | ||
| VHCP Co-Investment Holdings II, LLC | 1,885,668 | (1) | ||
| VHCP Management, LLC | 1,885,668 | (1) | ||
| VHCP Management II, LLC | 1,885,668 | (1) | ||
| Anders Hove | 1,885,668 | (1) | ||
| Bong Koh | 1,885,668 | (1) |
| (b) | Percent of Class as of March 3, 2016: |
| Venrock Healthcare Capital Partners, L.P. | 9.1 | % | ||||
| VHCP Co-Investment Holdings, LLC | 9.1 | % | ||||
| Venrock Healthcare Capital Partners II, L.P. | 9.1 | % | ||||
| VHCP Co-Investment Holdings II, LLC | 9.1 | % | ||||
| VHCP Management, LLC | 9.1 | % | ||||
| VHCP Management II, LLC | 9.1 | % | ||||
| Anders Hove | 9.1 | % | ||||
| Bong Koh | 9.1 | % | ||||
| (c) | Number of shares as to which the person has, as of March 3, 2016: |
| (i) | Sole power to vote or to direct the vote |
| Venrock Healthcare Capital Partners, L.P. | 0 | | ||
| VHCP Co-Investment Holdings, LLC | 0 | | ||
| Venrock Healthcare Capital Partners II, L.P. | 0 | | ||
| VHCP Co-Investment Holdings II, LLC | 0 | | ||
| VHCP Management, LLC | 0 | | ||
| VHCP Management II, LLC | 0 | | ||
| Anders Hove | 0 | | ||
| Bong Koh | 0 | |
| (ii) | Shared power to vote or to direct the vote |
| Venrock Healthcare Capital Partners, L.P. | 1,885,668 | (1) | ||
| VHCP Co-Investment Holdings, LLC | 1,885,668 | (1) | ||
| Venrock Healthcare Capital Partners II, L.P. | 1,885,668 | (1) | ||
| VHCP Co-Investment Holdings II, LLC | 1,885,668 | (1) | ||
| VHCP Management, LLC | 1,885,668 | (1) | ||
| VHCP Management II, LLC | 1,885,668 | (1) | ||
| Anders Hove | 1,885,668 | (1) | ||
| Bong Koh | 1,885,668 | (1) |
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