Natera Inc. (NTRA): Upside Potential Pulls Billionaire Stan Druckenmiller

Natera, Inc. (NASDAQ:NTRA) is one of Billionaire Stan Druckenmiller’s 10 Small and Mid-Cap Stock Picks with Huge Upside Potential.

Natera, Inc. (NASDAQ:NTRA) is the largest holding in the 13F portfolio of Duquesne Capital. The stock has consistently appeared in the portfolio of the fund since the third quarter of 2022. Back then, this position comprised just over 400,000 shares. The fund steadily increased this to over 3.5 million shares by the end of the fourth quarter of 2024. Since then, the stake has been trimmed. Filings for the fourth quarter of 2025 show that the fund owned 2.5 million shares in the firm, down over 21% compared to filings for the previous quarter.

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A major catalyst for Wall Street interest in Natera, Inc. (NASDAQ:NTRA) is the explosive growth of Signatera, Natera’s molecular residual disease (MRD) test. In early 2026, data showed that over 50% of all oncologists in the US had ordered a Signatera test in the previous quarter. Oncology test volumes grew by 55% year-over-year in Q4 2025. Institutional investors are betting that as Signatera becomes integrated into clinical guidelines for more cancer types, like breast and colorectal, the volume will become a massive, recurring revenue stream. Hedge funds have historically been wary of Natera’s high cash burn, but the narrative shifted in early 2026. Natera achieved a major goal in 2025 by generating $107.6 million in positive cash inflow. This removed the dilution risk that often plagues high-growth biotech stocks.

While we acknowledge the risk and potential of NTRA as an investment, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and doing so within a shorter time frame. If you are looking for an AI stock that is more promising than NTRA and that has 10,000% upside potential, check out our report about this cheapest AI stock.

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