Lone Pine’s Non-AI Strategy Falters: 5 Non-AI Stocks Weighing Down Stephen Mandel’s 2026 Returns

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1. Boston Scientific Corporation (NYSE:BSX)

Lone Pine Capital’s Stake: $19 Million

YTD Decline in Share Price: 37%

Boston Scientific Corporation (NYSE:BSX) is a new addition to the 13F portfolio of Lone Pine Capital. Filings for the fourth quarter of 2025 show that the fund owned a little over 200,000 shares in the company. Boston Scientific develops, manufactures, and markets medical devices for use in various interventional medical specialties worldwide. It offers devices to diagnose and treat a range of gastrointestinal conditions, such as resolution clips, biliary stent systems, stents and electrocautery enhanced delivery systems, and single-use scopes used for diagnostic and therapeutic procedures.

Boston Scientific Corporation (NYSE:BSX) beat Q1 estimates with $5.20 billion in revenue and $0.80 EPS, but the stock price experienced volatility because management lowered full-year 2026 guidance. Many hedge funds view this guidance cut, now projecting 6.5%–8% organic growth, as a strategic reset. By lowering the bar, management has cleared the way for future beat and raise quarters. Funds are particularly bullish on the Cardiovascular segment, which grew 11.2% organically in Q1. The Pulsed Field Ablation (PFA) platform of the firm remains a major structural moat. Recent clinical trials showed superior long-term success for atrial fibrillation treatment compared to traditional methods. Institutional investors are rewarding the 19% global growth of the WATCHMAN device as well. New data from the CHAMPION-AF study positioned it as a first-line option for stroke risk reduction.

While we acknowledge the potential of BSX to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than BSX and that has 100x upside potential, check out our report about the cheapest AI stock.

READ NEXT: 15 Safe Stocks to Invest In For Beginners and 10 Best Stocks to Buy According to Nancy Pelosi.

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