Inotek Pharmaceuticals Corp (ITEK): Billionaire Ken Griffin’ Citadel Investment Group Raises Stake to 6.5%

Billionaire Ken Griffin‘s Citadel Investment Group recently filed a Form 13G in which it reported raising its stake in Inotek Pharmaceuticals Corp (NASDAQ:ITEK) to 1.88 million common shares, which represent 6.5% of the company’s outstanding stock. This indicates a huge increase in the stake as the fund previously held only 16,909 shares, according to its last 13F filing, for the end of June.

Inotek Pharmaceuticals, as the name suggests it, is a clinical-stage biopharmaceutical company that mainly works on developing therapeutics to treat glaucoma and other eye diseases. Recently, the company reported the finalization of the recruitment phase of MATrX-1, the first phase 3 clinical trial of Trabodenoson, the company’s lead candidate, for the treatment of glaucoma. Over the past 12 months, Inotek Pharmaceuticals’ stock is down by 42.85%. For the second quarter of 2016, the company disclosed a loss per share of $0.33, and a net loss of $8.69 million, compared to a loss per share of $0.15 and a net loss of $2.39 million for the same quarter in the previous year. Earlier this month, Piper Jaffray Cos. reiterated its ‘Buy’ rating on Inotek Pharmaceuticals’ stock with a price target of $24.

CITADEL INVESTMENT GROUP

The number of hedge funds from our database long Inotek Pharmaceuticals (NASDAQ:ITEK) increased by one during the second quarter, and there were 12 hedge funds with positions in the company at the end of June. Among them were James A. Silverman’s Opaleye Management, which held a $4.8 million worth a position, Phill Gross and Robert Atchinson’s Adage Capital Management, with a position valued at $3.5 million, Principal Global Investors’ Columbus Circle Investors, Hal Mintz’ Sabby Capital, and Efrem Kamen’s Pura Vida Investments.

Brian Ashford-Russell And Tim Woolley’s Polar Capital initiated a new position in  Inotek Pharmaceuticals (NASDAQ:ITEK), during the quarter, and had invested $504,000, while Gregory Fraser, Rudolph Kluiber, And Timothy Krochuk’s GRT Capital Partners also acquired a new position, worth $427,000.

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You can access the original SEC filing by clicking here.

Ownership Summary Table

Name Sole Voting Power Shared Voting Power Sole Dispositive Power Shared Dispositive Power Aggregate Amount Owned Power Percent of Class
Citadel Advisors 0 1,871,258 0 6.5%
Citadel Advisors Holdings II 0 1,871,258 0 6.5%
Citadel GP 0 1,875,432 0 6.5%
Kenneth Griffin 0 1,875,432 0 6.5%

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Page 1 of 10 – SEC Filing

UNITED
STATES

SECURITIES
AND EXCHANGE COMMISSION

Washington,
D.C. 20549

  

SCHEDULE
13G

(Rule 13d-102)

 

Information Statement Pursuant
to Rules 13d-1 and 13d-2

Under the Securities Exchange
Act of 1934

(Amendment No. )*

 

 

Inotek Pharmaceuticals Corporation

(Name of Issuer)

Common stock, par value $0.01
per share

(Title of Class of Securities)

45780V102

(CUSIP Number)

August
22, 2016

Date of Event Which Requires Filing
of the Statement

Check the appropriate box to designate
the rule pursuant to which this Schedule is filed:

¨ Rule 13d-1(b)
x Rule 13d-1(c)
¨ Rule 13d-1(d)

*The remainder of this cover page shall
be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for
any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder
of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of
1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).

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Page 2 of 10 – SEC Filing

1.

NAME OF REPORTING PERSON

S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

Citadel Advisors LLC

2.

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ¨

(b)¨

3.

SEC USE ONLY

4.

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

 

1,871,258 shares

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

See Row 6 above

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

See Row 6 above

10.

CHECK BOX IF THE AGGREGATE AMOUNT
IN ROW (9) EXCLUDES

CERTAIN SHARES ¨

11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

6.5%1

12.

TYPE OF REPORTING PERSON

IA; OO; HC

1

The
percentages reported in this Schedule 13G are based upon 28,801,988 shares of common
stock outstanding (composed of (i) 26,930,730 shares of common stock outstanding as of
August 9, 2016 (according to the Form 10 Q filed by the issuer with the Securities and
Exchange Commission on August 10, 2016) and (ii) approximately 1,871,258 shares issuable
upon the conversion of certain convertible notes held by the Reporting Persons and certain
of their affiliates).

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Page 3 of 10 – SEC Filing

1.

NAME OF REPORTING PERSON

S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

Citadel Advisors Holdings II LP

2.

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ¨

(b)¨

3.

SEC USE ONLY

4.

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

 

1,871,258 shares

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

See Row 6 above

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

See Row 6 above

10.

CHECK BOX IF THE AGGREGATE AMOUNT
IN ROW (9) EXCLUDES

CERTAIN SHARES ¨

11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

6.5%

12.

TYPE OF REPORTING PERSON

PN; HC

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Page 4 of 10 – SEC Filing

1.

NAME OF REPORTING PERSON

S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

Citadel GP LLC

2.

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ¨

(b)¨

3.

SEC USE ONLY

4.

CITIZENSHIP OR PLACE OF ORGANIZATION

Delaware

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

 

1,875,432 shares

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

See Row 6 above.

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

See Row 6 above.

10.

CHECK BOX IF THE AGGREGATE AMOUNT
IN ROW (9) EXCLUDES

CERTAIN SHARES ¨

11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

6.5%

12.

TYPE OF REPORTING PERSON

OO; HC

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Page 5 of 10 – SEC Filing

1.

NAME OF REPORTING PERSON

S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

Kenneth Griffin

2.

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a) ¨

(b)¨

3.

SEC USE ONLY

4.

CITIZENSHIP OR PLACE OF ORGANIZATION

U.S. Citizen

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

5.

SOLE VOTING POWER

0

6.

SHARED VOTING POWER

 

1,875,432 shares

7.

SOLE DISPOSITIVE POWER

0

8.

SHARED DISPOSITIVE POWER

See Row 6 above

9.

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

See Row 6 above

10.

CHECK BOX IF THE AGGREGATE AMOUNT
IN ROW (9) EXCLUDES

CERTAIN SHARES ¨

11.

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

6.5%

12.

TYPE OF REPORTING PERSON

IN; HC

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Page 6 of 10 – SEC Filing

Item 1(a) Name of Issuer

Inotek Pharmaceuticals Corporation

 

Item 1(b) Address of Issuer’s Principal Executive Offices
91 Hartwell Avenue, Lexington, MA 02421
Item 2(a) Name of Person Filing
This Schedule 13G is being jointly filed by Citadel Advisors LLC (“Citadel Advisors”), Citadel Advisors Holdings II
LP (“CAH2”), Citadel GP LLC (“CGP”) and Mr. Kenneth Griffin (collectively with Citadel Advisors, CAH2
and CGP, the “Reporting Persons”) with respect to shares of common stock (and options to purchase and/or other securities
convertible into common stock) of the above-named issuer owned by Citadel Equity Fund Ltd., a Cayman Islands limited company (“CEF”),
and Citadel Securities LLC, a Delaware limited liability company (“Citadel Securities”).
Citadel Advisors is the portfolio manager for CEF. CAH2 is the managing member of Citadel Advisors. CALC III LP, a Delaware
limited partnership (“CALC3”), is the non-member manager of Citadel Securities. CGP is the general partner of CALC3
and CAH2. Mr. Griffin is the President and Chief Executive Officer of, and owns a controlling interest in, CGP.
The filing of this statement shall not be construed as an admission that any of the Reporting Persons is the beneficial owner
of any securities covered by the statement other than the securities actually owned by such person (if any).
Item 2(b) Address of Principal Business Office
The address of the principal business office of each of the Reporting Persons is c/o Citadel LLC, 131 S. Dearborn Street, 32nd
Floor, Chicago, Illinois 60603.
Item 2(c) Citizenship
Each of Citadel Advisors and CGP is organized as a limited liability company under the laws of the State of Delaware. CAH2 is
organized as a limited partnership under the laws of the State of Delaware. Mr. Griffin is a U.S. citizen.
Item 2(d) Title of Class of Securities
Common stock, $0.01 par value
Item 2(e) CUSIP Number
45780V102

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Page 7 of 10 – SEC Filing

 

Item 3 If this statement is filed pursuant to Rules 13d-1(b),
or 13d-2(b) or (c), check whether the person filing is a:
(a) ¨ Broker or dealer registered under Section 15
of the Exchange Act;
(b) ¨ Bank as defined in Section 3(a)(6) of the Exchange
Act;
(c) ¨ Insurance company as defined in Section 3(a)(19)
of the Exchange Act;
(d) ¨ Investment company registered under Section 8
of the Investment Company Act;
(e) ¨ An investment adviser in accordance with Rule
13d-1(b)(1)(ii)(E);
(f) ¨ An employee benefit plan or endowment fund in
accordance with Rule 13d-1(b)(1)(ii)(F);
(g) ¨ A parent holding company or control person in
accordance with Rule 13d-1(b)(1)(ii)(G);
(h) ¨ A savings association as defined in Section 3(b)
of the Federal Deposit Insurance Act;
(i) ¨ A church plan that is excluded from the definition
of an investment company under Section 3(c)(14) of the Investment Company Act;
(j) ¨ Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

If filing as
a non-U.S. institution in accordance with Rule 13d-1(b)(1)(ii)(J), please specify the type of institution: ____________.

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Page 8 of 10 – SEC Filing

 

Item 4 Ownership
A. Citadel Advisors LLC
(a) Citadel Advisors may be deemed to beneficially own 1,871,258 shares of common stock.
(b) The number of shares Citadel Advisors may be deemed to beneficially own constitutes approximately
6.5% of the common stock outstanding.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote: 0
(ii) shared power to vote or to direct the vote: 1,871,258
(iii) sole power to dispose or to direct the disposition of: 0
(iv) shared power to dispose or to direct the disposition of: 1,871,258
B. Citadel Advisors Holdings II LP
(a) CAH2 may be deemed to beneficially own 1,871,258 shares of common stock.
(b) The number of shares CAH2 may be deemed to beneficially own constitutes approximately 6.5% of the
common stock outstanding.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote: 0
(ii) shared power to vote or to direct the vote: 1,871,258
(iii) sole power to dispose or to direct the disposition of: 0
(iv) shared power to dispose or to direct the disposition of: 1,871,258

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Page 9 of 10 – SEC Filing

C. Citadel GP LLC and Kenneth Griffin
(a) CGP and Griffin may be deemed to beneficially own 1,875,432 shares of common stock.
(b) The number of shares CGP and Griffin may be deemed to beneficially own constitutes approximately 6.5%
of the common stock outstanding.
(c) Number of shares as to which such person has:
(i) sole power to vote or to direct the vote: 0
(ii) shared power to vote or to direct the vote: 1,875,432
(iii) sole power to dispose or to direct the disposition of: 0
(iv) shared power to dispose or to direct the disposition of: 1,875,432
Item 5 Ownership of Five Percent or Less of a Class
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial
owner of more than 5 percent of the class of securities, check the following ¨.

 

Item 6 Ownership of More than Five Percent on Behalf of Another
Person
Not Applicable

 

Item 7 Identification and Classification of the Subsidiary
which Acquired the Security Being Reported on by the Parent Holding Company
See Item 2 above

 

Item 8 Identification and Classification of Members of the
Group
Not Applicable
Item 9 Notice of Dissolution of Group
Not Applicable
Item 10 Certification
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and
are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and
were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

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Page 10 of 10 – SEC Filing

After reasonable inquiry
and to the best of its knowledge and belief, the undersigned certify that the information set forth in this statement is true,
complete and correct.

Dated this 29th day of August, 2016.

CITADEL ADVISORS LLC CITADEL ADVISORS HOLDINGS II LP
By: /s/ Mark Polemeni By: /s/ Mark Polemeni
Mark Polemeni, Authorized Signatory Mark Polemeni, Authorized Signatory
CITADEL GP LLC KENNETH GRIFFIN
   
By: /s/ Mark Polemeni By: /s/ Mark Polemeni
Mark Polemeni, Authorized Signatory Mark Polemeni,
attorney-in-fact*
* Mark Polemeni is signing on behalf of Kenneth Griffin as attorney-in-fact pursuant to a power of attorney previously filed
with the Securities and Exchange Commission on January 18, 2013, and hereby incorporated by reference herein. The power of attorney
was filed as an attachment to a filing by Citadel Advisors LLC on Schedule 13G for TiVo Inc.

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