How Oklo’s DOE Milestone Advanced Its Push Into Domestic Isotope Production

Oklo Inc. (NYSE:OKLO) is one of the top nuclear energy stocks to invest in for the next 5 years.

On March 17, 2026, Oklo said the U.S. Department of Energy approved the Nuclear Safety Design Agreement for Atomic Alchemy’s Groves Isotopes Test Reactor in Texas under the DOE’s Reactor Pilot Program. The company said the approval followed the signing of the facility’s Other Transaction Agreement in January and marked another step in the project’s authorization pathway. With the NSDA approved, the project now moves into the next phase under DOE oversight, with Atomic Alchemy set to submit its Preliminary Documented Safety Analysis for review.

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Oklo said the Groves facility is meant to help gather operating data, refine processes, and support future licensing submissions and later deployments. The company also said the reactor is intended to help establish more dependable domestic isotope production for uses including cancer diagnosis and treatment, advanced manufacturing, scientific research, space exploration, and national security. In the release, Oklo added that many isotopes are currently sourced from overseas suppliers or aging facilities. Atomic Alchemy is targeting criticality for the Groves facility by July 4, 2026.

Oklo Inc. (NYSE:OKLO) is an advanced nuclear technology company developing fast fission power plants, isotope production capabilities, and nuclear fuel recycling technologies.

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