Exact Sciences Corp (EXAS): D. E. Shaw Boosts Stake In High-Flying Stock

(b)

Address of Issuer’s Principal Executive Offices

441 Charmany Drive

Madison, WI 53719

D. E. Shaw & Co., L.P.

David E. Shaw

The business address for each reporting person is:

1166 Avenue of the Americas, 9^th Floor

New York, NY 10036

(c)

Citizenship

D. E. Shaw & Co., L.P. is a limited partnership organized
under the laws of the state of Delaware.

David E. Shaw is a citizen of the United States of America.

(d)

Title of Class of Securities

(e)

CUSIP Number

Item 3.

If this statement is filed pursuant to Rule 13d-1(b) or 13d-2(b)
or (c), check whether the person filing is a:

Not Applicable

Ownership

D. E. Shaw & Co., L.P.:

4,927,101 shares

This is composed of (i) 2,957,036 shares in the name
of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,658,971 shares in the name of D. E. Shaw Oculus Portfolios,
L.L.C., (iii) 161 shares in the name of D. E. Shaw Asymptote Portfolios, L.L.C., and (iv) 310,933 shares under the management
of D. E. Shaw Investment Management, L.L.C.

David E. Shaw:

4,927,101 shares

This is composed of (i) 2,957,036 shares in the name
of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,658,971 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., (iii) 161
shares in the name of D. E. Shaw Asymptote Portfolios, L.L.C., and (iv) 310,933 shares under the management of D. E. Shaw Investment
Management, L.L.C.