Exact Sciences Corp (EXAS): Billionaire David E. Shaw’s D E Shaw Ups Its Stake

441 Charmany Drive

Madison, WI 53719

D. E. Shaw & Co., L.P.

David E. Shaw

The business address for each
reporting person is:

1166 Avenue of the Americas,
9^th Floor

New York, NY 10036

D. E. Shaw & Co., L.P. is
a limited partnership organized under the laws of the state of Delaware.

David E. Shaw is a citizen of
the United States of America.

Common stock, par value $0.01

30063P105

If this statement is filed
pursuant to Rule 13d-1(b) or 13d-2(b) or (c), check whether the person filing is a:

Not Applicable

Ownership

D. E. Shaw & Co., L.P.:

5,440,212 shares

This is composed of (i) 3,306,923 shares in the name of D. E. Shaw
Valence Portfolios, L.L.C., (ii) 2,069,789 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii) 63,500
shares under the management of D. E. Shaw Investment Management, L.L.C.

David E. Shaw:

5,440,212 shares

This is composed of (i) 3,306,923 shares in the name of D. E.
Shaw Valence Portfolios, L.L.C., (ii) 2,069,789 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii) 63,500 shares
under the management of D. E. Shaw Investment Management, L.L.C.