D. E. Shaw Stock Portfolio: Top 5 Stocks to Buy

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1. NVIDIA Corporation (NASDAQ:NVDA)

D. E. Shaw’s Stake: $4.3 Billion

D. E. Shaw is among a handful of elite money managers who have been bullish on NVIDIA Corporation (NASDAQ:NVDA) since before it was an AI powerhouse. The fund has owned a stake in the company since late 2010. Back then, this position comprised 8.7 million shares. D. E. Shaw grew this to over 156 million shares in the second quarter of 2019. Since then, the holding has been trimmed. Filings for the fourth quarter of 2025 show that D. E. Shaw owns more than 23 million shares in the company, down over 8% compared to filings for the previous quarter. This is the first time in four quarters that the fund has trimmed the stake, having added to it significantly in the previous three quarters.

NVIDIA Corporation (NASDAQ:NVDA) remains one of the most prominent stock picks of elite investors, featuring heavily in the portfolios of the hedge fund managers with the highest returns in the past few decades. Several reasons explain this bullish view. In March 2026, NVIDIA CEO Jensen Huang updated the company’s long-term revenue opportunity to $1 trillion through 2027, a significant jump from previous estimates. Hedge funds have started moving away from viewing NVIDIA as a chip maker and instead value it as an integrated AI platform now. NVIDIA’s networking segment is growing nearly as fast as its compute segment. Funds are betting that the system-level integration is what will sustain 75%+ gross margins.

While we acknowledge the potential of NVDA to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than NVDA and that has 100x upside potential, check out our report about the cheapest AI stock.

READ NEXT: 33 Stocks That Should Double in 3 Years and 15 Stocks That Will Make You Rich in 10 Years. 

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