D. E. Shaw Stock Portfolio: Top 5 Stocks to Buy

4. Advanced Micro Devices, Inc. (NASDAQ:AMD)

D. E. Shaw’s Stake: $1.5 Billion

D. E. Shaw has registered a major buying activity around Advanced Micro Devices, Inc. (NASDAQ:AMD) stock in the fourth quarter of 2025. Although the semiconductor firm is a long-term holding of the hedge fund, first featuring the 13F portfolio way back at the end of 2010, in recent quarters, the fund had reduced it from 9.2 million shares in the fourth quarter of 2023 to just 350,000 shares in the third quarter of 2025. However, in the fourth quarter of 2025, the fund upped this by 1,917%, growing the shares owned to more than 7 million.

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Elite hedge funds often prefer the risk-reward profile of Advanced Micro Devices, Inc. (NASDAQ:AMD) over rivals like NVIDIA. In early 2026, AMD traded at roughly 11x sales, compared to Nvidia’s 23x sales. Many managers argue that if AMD captures just 15%-20% of the AI accelerator market, up from 9% in 2025, the stock could see a massive multiple re-rating toward NVIDIA levels. Another important factor investors keep in mind while investing in AMD is that while AI GPUs get the headlines, AMD’s CPUs continue to grab market share from chip powerhouse Intel in the traditional data center market. AMD management has signaled a path toward 50% server CPU revenue share by the end of 2026. The 6th Gen EPYC chips launching in late 2026 are expected to drive a 40% year-over-year surge in server revenue.