D. E. Shaw & Co Raises Exposure to Biocryst Pharmaceuticals Inc (BCRX)

(b)

Address of Issuer’s Principal Executive Offices

4505 Emperor Blvd., Suite 200

Durham, North Carolina 27703

D. E. Shaw & Co., L.P.

David E. Shaw

The business address for each reporting person is:

1166 Avenue of the Americas, 9^th Floor

New York, NY 10036

(c)

Citizenship

D. E. Shaw & Co., L.P. is a limited partnership organized
under the laws of the state of Delaware.

David E. Shaw is a citizen of the United States of America.

(d)

Title of Class of Securities

(e)

CUSIP Number

Item 3.

If this statement is filed pursuant to Rule 13d-1(b) or 13d-2(b)
or (c), check whether the person filing is a:

Not Applicable

Ownership

D. E. Shaw & Co., L.P.:

3,750,783 shares

This is composed of (i) 2,139,058 shares in the name
of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,142,180 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., (iii) 8,123
shares in the name of D. E. Shaw Asymptote Portfolios, L.L.C., and (iv) 461,422 shares under the management of D. E. Shaw
Investment Management, L.L.C.

David E. Shaw:

3,750,783 shares

This is composed of (i) 2,139,058 shares in the name
of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,142,180 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., (iii) 8,123
shares in the name of D. E. Shaw Asymptote Portfolios, L.L.C., and (iv) 461,422 shares under the management of D. E. Shaw Investment
Management, L.L.C.