Cogent (COGT) Presents Preclinical Data for Novel JAK2 Inhibitor CGT1145 at 2026 EHA Congress

Cogent Biosciences Inc. (NASDAQ:COGT) is one of the best upside stocks to buy according to hedge funds. On June 12, Cogent Biosciences presented promising preclinical data at the 2026 EHA Congress for its novel inhibitor, CGT1145, which targets the JAK2 V617F mutation. This candidate is designed to be a best-in-class therapy, showing over 100-fold selectivity for the mutant protein compared to wild-type JAK2 and other isoforms. These properties suggest a potential to treat myeloproliferative neoplasms/MPNs more effectively while reducing the off-target side effects often seen with currently approved treatments.

The data indicates that CGT1145 exhibits high oral bioavailability and could potentially induce molecular remission by eradicating disease-propagating cells. By addressing the primary mutational driver of these conditions with improved hematological tolerability, the program aims to offer a significant advancement over existing JAK inhibitors.

Cogent (COGT) Presents Preclinical Data for Novel JAK2 Inhibitor CGT1145 at 2026 EHA Congress

Cogent Biosciences Inc. (NASDAQ:COGT) is currently advancing the development of this program and remains on schedule to submit an Investigational New Drug (IND) application later in 2026. This progress underscores the company’s commitment to developing precision therapies for patients with genetically defined diseases, particularly in the MPN space where JAK2 V617F remains a prevalent and critical target.

Cogent Biosciences Inc. (NASDAQ:COGT) is a biotechnology company that develops precision therapies for genetically defined diseases.

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