Biocryst Pharmaceuticals Inc (BCRX): Billionaire David E. Shaw’s Fund Increases Stake

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SIGNATURE

After reasonable inquiry and to the best of their knowledge
and belief, the undersigned certify that the information set forth in this statement is true, complete and correct. A Power of
Attorney, dated December 16, 2014, granted by David E. Shaw in favor of Nathan Thomas, is attached hereto.

Dated: August 22, 2016

D. E. Shaw & Co., L.P.
By: /s/ Nathan Thomas
Nathan Thomas
Chief Compliance Officer
David E. Shaw
By: /s/ Nathan Thomas
Nathan Thomas
Attorney-in-Fact for David E. Shaw

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