Biocryst Pharmaceuticals Inc (BCRX): Billionaire David E. Shaw’s Fund Increases Stake

(b)

Address of Issuer’s Principal Executive Offices

4505 Emperor Blvd., Suite 200

Durham, NC 27703

D. E. Shaw & Co., L.P.

David E. Shaw

The business address for each reporting person is:

1166 Avenue of the Americas, 9^th Floor

New York, NY 10036

(c)

Citizenship

D. E. Shaw & Co., L.P. is a limited partnership organized
under the laws of the state of Delaware.

David E. Shaw is a citizen of the United States of America.

Item 3.

If this statement is filed pursuant to Rule
13d-1(b) or 13d-2(b) or (c), check whether the person filing is a:

Not Applicable

D. E. Shaw & Co., L.P.:

3,740,239 shares

This is composed of (i) 1,912,534 shares in the name
of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,426,384 shares in the name of D. E. Shaw Oculus Portfolios,
L.L.C., and (iii) 401,321 shares under the management of D. E. Shaw Investment Management, L.L.C.

David E. Shaw:

3,740,239 shares

This is composed of (i) 1,912,534 shares in the name
of D. E. Shaw Valence Portfolios, L.L.C., (ii) 1,426,384 shares in the name of D. E. Shaw Oculus Portfolios, L.L.C., and (iii)
401,321 shares under the management of D. E. Shaw Investment Management, L.L.C.