Joel Beatty : Great. And then for the cardio drugs APOC3 and ANG3, do you see the market opportunity as more of displacing current drugs and being used in place with them or as add-on therapies to the current set of drugs in the market?
Christopher Anzalone: I think it’s a little bit too early to opine on that. That’s a broad question. Give us some more time so we can complete the Phase 2, and we have a better idea about what that looks like and we can go from there. But at this point, I don’t think that we want to get into how we slot into various therapeutic paradigms.
Operator: And our next question comes from Edward Tenthoff from Piper Sandler.
Edward Tenthoff : Two questions, if I may. Just housekeeping, what was the fourth quarter weighted average shares outstanding, if you have them to 3 decimal points? But then for Chris, kind of level question. You guys have been so successful at partnering different therapies. You’ve been clear that cardiovascular is a key area of focus. How are you really looking at the pipeline going forward? Like is pulmonary disease going to be an area of a secondary focus? Are you going to look to partner some of those therapies? How should we be thinking about sort of where you guys are going to stay focused and specialized?
Christopher Anzalone: Sure. Ken, do you want to address the first question?
Ken Myszkowski : Yes. The weighted average shares for Q4 were 105.879 million
Edward Tenthoff : Awesome. And then again, just in terms of higher level, obviously, a focus on cardiovascular disease. What else are you guys thinking about partnering or what is going to be core?
Christopher Anzalone: Sure. Thanks, Ed. So broadly, of course, that’s a dynamic question because as the company grows and as market appetites for various targets and drugs change, of course, that which can be partnered changes. Having said all of that, look, we — as we’ve said in the past, we like cardiovascular. We like what we’re seeing with APOC3 and ANG3. We like the idea of building commercial force to address those. We like the staged approach there starting with HoFH and expanding into HeFH. We like the idea of starting with small FCS, expanding into SHTG, and expand into mixed dyslipidemia. Now with regard to the pulmonary, look, that’s a very interesting area. We think that’s a target-rich environment. That feels to us like another liver.
And we think, look, there we can address that market. I think there are 600-or-so-thousand pulmonologists in the U.S., and we see not two or three or four drugs with eight or nine or 10 drugs. So I think that we will play there. Now because it’s so target rich, I think we also could do some partnerships there at some point. We’re not looking to partner these first three right now. But I think there’s room there for us to build a real franchise. And then also to work with the right companies on a handful of other targets potentially. And then you look at our other candidates, C3, that’s a very interesting drug candidate to hold on to ourselves. That gives us an awful lot of optionality in terms of how we commercialize that, where we go, how fast we can get there.
So anyways, so that’s sort of a broad answer to your question, I guess.
Edward Tenthoff : And just hats off on the Royalty financing. That was a great deal.
Christopher Anzalone: Thank you.
Operator: And our next question comes from Patrick Trucchio from H.C. Wainright.
Patrick Trucchio : I’m just wondering, I have a follow-up just on the platform. And if you can discuss the relative advantages of the siRNA approach as it compares to others such as small molecules or gene editing, specifically in the area of alpha-1. So also more broadly across the pipeline, what is your level of confidence that siRNA will be the preferred mechanism in these various targets and indications and the programs currently underway, particularly as these other modalities advance in clinical development?
