We’re seeing substantial reduction in viral antigens. I think that’s important that is maybe the critical component to getting to a functional cure. It’s not the only component, but I think it’s the critical one, and they were interrogating a number of different strategies to what they can combine with that to get to functional cures. We look forward to seeing more of those data because we are only so close to it at this point, of course.
Maury Raycroft: Got it. Okay, makes sense. I will hop back in queue. Thanks for taking my questions.
Christopher Anzalone: Yes. Thank you.
Operator: Thank you. Our next question comes from the line of Mayank Mamtani from B. Riley. Your line is open., Mayank.
Mayank Mamtani: Hi, thanks for taking questions. Looks like a busy year 2023 for you than last year. So maybe just following up on the pulmonary programs. on the safety and tolerability data that we will have for RAGE and MUC5A, could you talk about sort of the implications of that broadly for your delivery system? And just maybe remind us of the nebulizer system is the same across the different programs. And a second part question on the MMP7. What is the frequency of administration you’re looking to target there? As you know, in IPF. Now there is a lot of progress in the pipeline with some antibody approaches also coming in.
James Hamilton: Sure. Yes. So I think the safety data that we will have for RAGE and MUC5AC, I think while it will be candidate specific and target specific, I think will be applicable to the broader platform and will help to support the pulmonary delivery platform generally. In terms of the nebulizer question, this is €“ it’s the same nebulizer system that we’re using across the three different programs. It’s different than what we used with ARO-ENaC. So this is a more efficient nebulizer versus what we used with ENaC. And then there was a third question there, I think…
Christopher Anzalone: MMP7 dose interval.
James Hamilton: So the initial dosing interval for MMP7 is every 2 weeks in the MAD cohorts. In the SAD, of course, we just do single doses, but then we’re investigating day 1, 15 and 29 in MM7 similar to what we’re doing in the MAD cohorts for MUC5AC. Now that may not be the dosing regimen going forward. That’s sort of a more intensive regimen consistent with what we used in the animals to generate maximum knockdown. We will have to see what the duration of knockdown is after both a single dose and after the multi-dose administration.
Mayank Mamtani: Got it. And then just a quick follow-up on JNJ-0795, can you just remind us what the target there is and sort of the progress €“ how far along that program is €“ I know it’s a J&J partnered program. And then just broadly on the on sort of the partnership with J&J. Is it product program-by-program, I am assuming and whatever happens with 3989 has no implications on how things may progress with 0795?
James Hamilton: Yes. Those are different divisions within Janssen. The target is PNPLA3 a €“ gosh, maybe the most genetically validated target for NASH. They are in a Phase 1 study that includes SAD as well as the MAD portion. And it is my expectation that we can start to report at least some, not at least certainly some SAD data this quarter.
Mayank Mamtani: Okay. Thanks for taking the question.
Operator: Thank you. Our next question comes from the line of Joel Beatty of Baird. Your line is open, Joel. Again Joel Beatty of Baird, your line is open.
Joel Beatty: Hello. Can you hear me?
Operator: Yes.
Joel Beatty: So, for the lung programs and the data coming in Q2, could you elaborate on how meaningful the data is for other programs? In the prepared remarks, you talked about eight or nine programs that could come for long. How de-risking is this data that we get in Q2?
