In this article, we will discuss the 9 Most Active US Stocks to Buy Right Now.
On April 29, Joe Amato, Neuberger President and CIO, joined ‘Squawk Box’ to discuss the current state of the capital markets, noting that while there has been a significant snapback rally following the Iran conflict, the rebound has been surprisingly narrow. Amato observed that the broadening out trade seen late last year and early this year was interrupted in March by a 9% drawdown. Since then, the tech and semiconductor sectors have driven the recovery, with semiconductors rising roughly 30% to 35% over the past month. Despite the aggressive bounce-back in Mag 7 stocks, he expressed a desire for a more inclusive market rally.
Amato expects the broadening out theme to return eventually as non-tech sectors begin to show better earnings. However, he acknowledged that technology remains the dominant force, with tech sector earnings expected to rise by about 30%. He noted that while the chip, material, and energy sectors have seen estimated upgrades, financials are also performing well and are expected to be up 20% this quarter. He concluded that while market multiples were stretched at the beginning of the year, the recent growth in earnings has made them more manageable, keeping him comfortable with equity risks.
Our Methodology
We used Yahoo Finance’s “most active stocks” screen to identify US stocks with a high 3-month average volume, and limited our final selection to companies that have recently reported noteworthy developments likely to impact investor sentiment. These stocks are also popular among analysts and elite hedge funds.
Note: All data was sourced on April 28.
Why are we interested in the stocks that hedge funds pile into? The reason is simple: our research has shown that we can outperform the market by imitating the top stock picks of the best hedge funds. Our quarterly newsletter’s strategy selects 14 small-cap and large-cap stocks every quarter and has returned 498.7% since May 2014, beating its benchmark by 303 percentage points (see more details here).
9 Most Active US Stocks to Buy Right Now
9. Pfizer Inc. (NYSE:PFE)
Pfizer Inc. (NYSE:PFE) is one of the most active US stocks to buy right now. On April 28, Pfizer entered into settlement agreements with generic drug manufacturers Dexcel Pharma, Hikma Pharmaceuticals, and Cipla Ltd, resolving patent infringement litigation regarding VYNDAMAX (tafamidis). These agreements effectively extend Pfizer’s US patent protection for the transthyretin-mediated amyloidosis (ATTR-CM) treatment until June 1, 2031. This is a significant shift from previous projections, which anticipated a sharp revenue decline starting in 2029 due to patent expiration.
The extension secures VYNDAMAX’s market-leading position, where it currently holds 75% of prescription volume in the ATTR-CM space. Pfizer expects revenues for the drug to remain stable from 2028 through mid-2031, supported by over seven years of clinical data and its status as the only once-daily capsule proven to reduce all-cause mortality and cardiovascular hospitalizations. Aamir Malik, Pfizer’s Chief US Commercial Officer, emphasized that the outcome validates the company’s innovative science and ensures continued access for patients.
In a move to streamline patient care, Pfizer Inc. (NYSE:PFE) also confirmed it discontinued the supply of VYNDAQEL in the US as of late 2025, leaving VYNDAMAX as the primary available option. The decision was made in consultation with clinical experts to prioritize the convenience of the once-daily, single-capsule regimen. This consolidation, paired with the recent legal settlements, reinforces Pfizer’s long-term commercial strategy for its cardiovascular portfolio through the next decade.
Pfizer Inc. (NYSE:PFE) is a global biopharmaceutical company that manufactures, develops, markets, and sells biopharmaceutical products worldwide. It advances wellness, prevention, treatment, and cures in developing and emerging markets, and is also involved in developing immunotherapies that help the immune system to recognise and attack cancer cells.
8. BitMine Immersion Technologies Inc. (NYSE:BMNR)
BitMine Immersion Technologies Inc. (NYSE:BMNR) is one of the most active US stocks to buy right now. On April 27, Bitmine Immersion achieved a world-record treasury milestone, announcing that its Ethereum holdings have reached 5.078 million ETH, valued at ~$12 billion. This stockpile represents 4.21% of the total global ETH supply, placing the company within reach of its “Alchemy of 5%” acquisition goal in just ten months.
Combined with $940 million in cash and strategic moonshot investments (including a $91 million stake in Eightco (NASDAQ:ORBS) for OpenAI exposure), Bitmine’s total holdings now stand at $13.3 billion. The company’s aggressive accumulation strategy is supported by its recent uplisting to the NYSE on April 9. Chairman Thomas Lee highlighted that ETH has emerged as a premier “wartime store of value,” significantly outperforming the S&P 500 amid regional conflicts.
Bitmine is also utilizing its holdings through its institutional-grade staking platform, MAVAN (Made in America Validator Network). Currently, the company has staked 3.7 million ETH, generating an annualized staking revenue of $264 million with a yield of 3.033%. BitMine Immersion Technologies Inc. (NYSE:BMNR) now ranks as the world’s largest corporate ETH treasury and the second-largest global crypto treasury overall, trailing only MicroStrategy.
BitMine Immersion Technologies Inc. (NYSE:BMNR) is a digital asset company. It was originally focused on Bitcoin mining and hosting services, but has pivoted toward building a massive Ethereum treasury. The company has also developed infrastructure such as its MAVAN validator network, which serves as an institutional-grade Ethereum staking platform.
7. Transocean Ltd. (NYSE:RIG)
Transocean Ltd. (NYSE:RIG) is one of the most active US stocks to buy right now. On April 2, Transocean secured new contracts and extensions in Norway and Brazil totaling ~$1.0 billion in firm backlog. In Norway, the harsh environment semisubmersible Transocean Barents was awarded a 3-year contract with Vår Energi ASA at a day rate of $450,000, contributing $490 million to the backlog with options extending potentially into 2034.
In Brazil, Petrobras awarded a three-year extension to the Deepwater Orion and a one-year extension to the Deepwater Aquila, committing the vessels through March 2030 and June 2028, respectively. Alongside these operational milestones, Transocean fully retired its 8.375% Senior Secured Notes due 2028 (Titan Notes) on March 20.
The company used cash on hand and debt service reserve funds to settle the $358 million outstanding principal. This move is expected to generate ~$39 million in interest savings to maturity, aligning with the firm’s strategic focus on simplifying its balance sheet and reducing overall interest expenses. Looking ahead, Transocean Ltd. (NYSE:RIG) expects to retire a total of $0.75 billion of debt in 2026 as part of its ongoing deleveraging strategy.
Transocean Ltd. (NYSE:RIG) provides offshore drilling services for oil and gas exploration and development worldwide.
6. Amazon.com Inc. (NASDAQ:AMZN)
Amazon.com Inc. (NASDAQ:AMZN) is one of the most active US stocks to buy right now. On April 28, Amazon Web Services/AWS and OpenAI announced an expanded partnership to integrate OpenAI’s frontier intelligence into the Amazon Bedrock ecosystem. Available in limited preview, this collaboration allows enterprises to access the latest OpenAI models through the same Bedrock APIs and governance controls they already use.
By unifying OpenAI’s reasoning capabilities with AWS’s institutional-grade security, such as IAM-based access and CloudTrail logging, organizations can now deploy these advanced models alongside existing providers like Anthropic and Meta within a single, consistent service. The partnership also introduces Codex on Amazon.com Inc. (NASDAQ:AMZN) Bedrock, bringing OpenAI’s premier coding agent directly into the AWS environments where enterprise teams build and operate.
This integration allows developers to automate coding tasks, refactor systems, and accelerate delivery while using their existing AWS credentials and infrastructure. Because Codex usage now applies toward AWS cloud commitments, procurement and financial governance are streamlined for organizations managing large-scale software development workloads on the world’s most adopted cloud.
Amazon.com Inc. (NASDAQ:AMZN) operates across e-commerce, digital content, advertising, and cloud computing. Its online and offline stores offer both in-house and third-party products, while its AWS division runs one of the world’s largest data center networks.
While we acknowledge the potential of AMZN to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than AMZN and that has 100x upside potential, check out our report about the cheapest AI stock.
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