9 Best Small Cap Stocks with Biggest Upside Potential

2. Janux Therapeutics Inc. (NASDAQ:JANX)

Market Capitalization as of August 15: $1.51 billion

Number of Hedge Fund Holders: 41

Average Upside Potential as of August 15: 218.60%

Janux Therapeutics Inc. (NASDAQ:JANX) is one of the best small cap stocks with biggest upside potential. On August 5, Janux Therapeutics announced a clinical milestone in its collaboration with Merck & Co. Inc. (NYSE:MRK), with the first patient being dosed in a lead program from their partnership. This achievement triggered a $10 million milestone payment to Janux.

The collaboration, which was established in December 2020, makes Janux eligible for additional development and commercial milestone payments, as well as royalties. Janux Therapeutics’ platforms are engineered to selectively modulate immune cells to fight cancer. A T cell engager is a type of bispecific antibody that brings T cells (a type of immune cell) and cancer cells into proximity, enabling the T cells to kill the cancer cells more effectively.

Janux’s technology is designed to overcome limitations of traditional T-cell engagers by being activated only within the tumor microenvironment, which aims to reduce toxicity and improve efficacy. Janux currently has two TRACTr candidates in Phase 1 clinical trials: JANX007, which targets prostate-specific membrane antigen/PSMA, and JANX008, which targets epidermal growth factor receptor/EGFR.

Janux Therapeutics Inc. (NASDAQ:JANX) is a clinical-stage biopharmaceutical company that develops immunotherapies based on Tumor Activated T Cell Engager/TRACTr and Tumor Activated Immunomodulator/TRACIr platforms technology to treat patients with cancer.

Merck & Co. Inc. (NYSE:MRK) is a healthcare company that operates through 2 segments: Pharmaceutical and Animal Health.