9 Best Biotech Penny Stocks to Buy in 2026

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6. ProKidney Corp. (NASDAQ:PROK)

Number of Hedge Fund Holders: 15

ProKidney Corp. (NASDAQ:PROK) is one of the best biotech penny stocks to buy in 2026. On March 25, ProKidney appointed Greg Madison as Chief Commercial Officer, a move aimed at preparing the company for the potential launch of its lead cell therapy, rilparencel. Reporting to CEO Bruce Culleton, M.D., Madison is tasked with shaping the commercial infrastructure and market strategy for the treatment, which is currently in late-stage clinical development for patients with advanced chronic kidney disease/CKD and diabetes.

Madison brings 20+ years of biopharma leadership, with an emphasis on nephrology and specialty markets. His prior experience includes serving as CEO of Shield Therapeutics and Melt Pharmaceuticals, as well as President and CEO of Keryx Biopharmaceuticals. During his tenure at Genzyme, Madison served as VP and GM of the Global Renal Business, where he was instrumental in driving the renal therapies Renagel and Renvela to blockbuster status with more than $1 billion in annual revenue.

The appointment comes as ProKidney Corp. (NASDAQ:PROK) targets a significant unmet need in the US, where ~37 million adults suffer from CKD. Rilparencel is specifically being developed for the Stage 3b/4 CKD population, which includes over 1 million individuals in the US whose disease is driven by diabetes.

ProKidney Corp. (NASDAQ:PROK) is engaged in developing cell therapies for the treatment of chronic kidney diseases. Its product portfolio includes rilparencel, which is in Phase III of clinical trial. Alongside this, the company is developing different cryopreserved versions of rilparencel, with each one in a different phase of clinical trials.

While we acknowledge the potential of PROK to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than PROK and that has 100x upside potential, check out our report about the cheapest AI stock.

Click to continue reading and see the 5 Best Biotech Penny Stocks to Buy in 2026.

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