5 Small Cap Stocks with Potential to Rise 1000 Percent

4. Autolus Therapeutics plc (NASDAQ:AUTL)

Autolus Therapeutics plc (NASDAQ:AUTL) is one of the small-cap stocks with potential to rise 1000 percent. Unlike many biotech companies that are still waiting for their first approved product, Autolus already has a treatment on the market. Its drug AUCATZYL, also known as obe-cel, is approved for adults with a hard-to-treat form of blood cancer called relapsed or refractory B-cell acute lymphoblastic leukemia. In its May 14 first-quarter update, Autolus reported $26.2 million in AUCATZYL net product revenue, up from $9.0 million a year earlier, and said the business reached positive gross margin for the first time.

Autolus also kept its 2026 AUCATZYL revenue guidance at $120 million to $135 million, compared with $74 million in 2025. The company is trying to expand obe-cel beyond its first approved use, with studies in pediatric ALL, lupus nephritis, and progressive multiple sclerosis. On May 21, Autolus said an ASCO abstract from the FELIX study showed a 59% overall remission rate and a 42.6-month median duration of response in patients whose cancer had spread outside the bone marrow, a difficult-to-treat subgroup. Autolus ended the first quarter with $229.4 million in cash, cash equivalents, and marketable securities, enough to fund operations into the fourth quarter of 2027.

Autolus Therapeutics plc (NASDAQ:AUTL) is a commercial-stage biopharmaceutical company developing programmed T-cell therapies for cancer and autoimmune diseases.