5 High Yield Fortune 500 Stocks to Buy Now

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1. Pfizer Inc. (NYSE:PFE

Dividend Yield as of June 11: 6.57%

Topping our list of the Best Fortune 500 Dividend Stocks is Pfizer Inc. (NYSE:PFE). The company discovers, develops, manufactures, markets, distributes, and sells biopharmaceutical products in the United States and internationally. The company’s global portfolio includes medicines and vaccines, as well as many of the world’s best-known consumer health care products.

On June 10, Pfizer Inc. (NYSE:PFE) was upgraded by RBC Capital analyst Trung Huynh from ‘Underperform’ to ‘Sector Perform’. Mr. Huynh assigned the stock a price target of $25, indicating a downside of 5% from the current levels.

RBC noted that its overall investment outlook on Pfizer has not substantially changed. However, with the stock down by over 8% from its highs earlier this year and now trading at around 9-times forward earnings, the analyst firm believes that it offers a more balanced risk-reward profile.

RBC also highlighted two key catalysts for Pfizer – Sigvotatug vedotin in second-line lung cancer in mid-2026 and mevro in the latter half of this year. Moreover, the analyst highlighted the pharma company’s strong Q1 fundamentals that should support a potential 2026 guidance upgrade, as well as its robust dividend yield of 6.57%, which may help limit downside risk.

While we acknowledge the potential of PFE to grow, our conviction lies in the belief that some AI stocks hold greater promise for delivering higher returns and have limited downside risk. If you are looking for an AI stock that is more promising than PFE and that has 100x upside potential, check out our report about the cheapest AI stock.

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