5 Cities with the Highest Opioid Deaths in the U.S.

4. Philadelphia, Pennsylvania

Opioid-related drug overdose deaths (per 100,000 population, age-adjusted): 53,5

Philadelphia ranks in the list of the top ten cities in America in terms of population. However, while it is the sixth most populous city with a population of 1.6 million, its opioid related overdose deaths make it rank fourth on our list. Philadelphia is also one of the most historic cities in America. It is known to be the founding place of the U.S., being a regular meeting point of the Founding Fathers before the American Revolution. Naturally, this also made it the first capital of the United States of America.