5 Cities with the Highest Depression Rates in the U.S.

4. Charleston, West Virginia

Percentage of Residents With Depression: 29.00%

Charleston is the largest city in West Virginia in terms of population. It is also the state’s capital city and one of the oldest in the U.S. since 1788 – soon after the American Revolution as the first settlers moved to the area for its resources after the war. The average income in Charleston are quite low, with the 2020 census showing that the median household income in the city was $54,101 – with a significant portion of its population also living below the poverty line.