5 Best Performing Small Cap Stocks So Far in 2026

4. Shattuck Labs, Inc. (NASDAQ:STTK)

Shattuck Labs, Inc. (NASDAQ:STTK) is one of the best performing small cap stocks so far in 2026. Cantor Fitzgerald initiated coverage of Shattuck Labs, Inc. (NASDAQ:STTK) with an Overweight rating on April 27, telling investors in a research note that the stock’s more than 800% rise over the last 12 months points towards enthusiasm for its DR3 and TL1A programs. It added that investors are betting on differentiated efficacy and upcoming early-phase data that could de-risk key drug attributes, and that continued clinical readouts across several autoimmune indications and interest in combination or bispecific approaches could further support upside.

Shattuck Labs, Inc. (NASDAQ:STTK) also received a rating update from H.C. Wainwright on April 20. The firm lifted the price target on the stock to $18 from $6, reiterating a Buy rating on the shares. The firm raised its projected SL-325 probability of success to 15% from 10% based on projections for a broad positive upcoming dataset.

Shattuck Labs, Inc. (NASDAQ:STTK) is a biotechnology company involved in the research and development of potential treatments for inflammatory and immune-mediated diseases. The company’s focus is on the development of a potential first-in-class antibody to treat inflammatory bowel disease (IBD) and other inflammatory and immune-mediated diseases.